An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene

F. R. Ali; A. Barton; R. L. I. Smith; J. Bowes; E. Flynn; M. Mangino; V. Bataille; J. P. Foerster; J. Worthington; C. E. M. Griffiths; R. B. Warren

doi:10.1111/bjd.12106

An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene

F. R. Ali, A. Barton, R. L. I. Smith, J. Bowes, E. Flynn, M. Mangino, V. Bataille, J. P. Foerster, J. Worthington, C. E. M. Griffiths, R. B. Warren

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Background Phenotypically diverse autoimmune conditions share common genetic susceptibility loci and underlying molecular pathways.

Objectives By systematically searching for single nucleotide polymorphisms (SNPs) associated with another autoimmune disease, rheumatoid arthritis (RA), we aimed to elucidate novel genetic markers of psoriasis.

Methods We investigated 18 SNPs, previously confirmed as being associated with RA, in a U. K. cohort of 623 patients with early-onset psoriasis (presenting before age 40 years), comparing them with 2662 control subjects.

Results Our findings confirm the association of early-onset psoriasis with REL (rs13031237, P = 0.0027). The minor allele of REL had opposing effects upon susceptibility to disease in patients with psoriasis and RA.

Conclusion Similar exploration of additional autoimmune loci and fine mapping of such regions may provide further insight into the genetics and molecular pathophysiology of psoriasis.

Original language	English
Pages (from-to)	864-866
Number of pages	3
Journal	British Journal of Dermatology
Volume	168
Issue number	4
DOIs	https://doi.org/10.1111/bjd.12106
Publication status	Published - Apr 2013

Keywords

GENOME-WIDE ASSOCIATION
SUSCEPTIBILITY LOCI
CROHN DISEASE

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Ali, F. R., Barton, A., Smith, R. L. I., Bowes, J., Flynn, E., Mangino, M., Bataille, V., Foerster, J. P., Worthington, J., Griffiths, C. E. M., & Warren, R. B. (2013). An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene. British Journal of Dermatology, 168(4), 864-866. https://doi.org/10.1111/bjd.12106

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title = "An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene",

abstract = "Background Phenotypically diverse autoimmune conditions share common genetic susceptibility loci and underlying molecular pathways.Objectives By systematically searching for single nucleotide polymorphisms (SNPs) associated with another autoimmune disease, rheumatoid arthritis (RA), we aimed to elucidate novel genetic markers of psoriasis.Methods We investigated 18 SNPs, previously confirmed as being associated with RA, in a U. K. cohort of 623 patients with early-onset psoriasis (presenting before age 40 years), comparing them with 2662 control subjects.Results Our findings confirm the association of early-onset psoriasis with REL (rs13031237, P = 0.0027). The minor allele of REL had opposing effects upon susceptibility to disease in patients with psoriasis and RA.Conclusion Similar exploration of additional autoimmune loci and fine mapping of such regions may provide further insight into the genetics and molecular pathophysiology of psoriasis.",

keywords = "GENOME-WIDE ASSOCIATION, SUSCEPTIBILITY LOCI, CROHN DISEASE",

author = "Ali, {F. R.} and A. Barton and Smith, {R. L. I.} and J. Bowes and E. Flynn and M. Mangino and V. Bataille and Foerster, {J. P.} and J. Worthington and Griffiths, {C. E. M.} and Warren, {R. B.}",

year = "2013",

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doi = "10.1111/bjd.12106",

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T1 - An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene

AU - Ali, F. R.

AU - Barton, A.

AU - Smith, R. L. I.

AU - Bowes, J.

AU - Flynn, E.

AU - Mangino, M.

AU - Bataille, V.

AU - Foerster, J. P.

AU - Worthington, J.

AU - Griffiths, C. E. M.

AU - Warren, R. B.

PY - 2013/4

Y1 - 2013/4

N2 - Background Phenotypically diverse autoimmune conditions share common genetic susceptibility loci and underlying molecular pathways.Objectives By systematically searching for single nucleotide polymorphisms (SNPs) associated with another autoimmune disease, rheumatoid arthritis (RA), we aimed to elucidate novel genetic markers of psoriasis.Methods We investigated 18 SNPs, previously confirmed as being associated with RA, in a U. K. cohort of 623 patients with early-onset psoriasis (presenting before age 40 years), comparing them with 2662 control subjects.Results Our findings confirm the association of early-onset psoriasis with REL (rs13031237, P = 0.0027). The minor allele of REL had opposing effects upon susceptibility to disease in patients with psoriasis and RA.Conclusion Similar exploration of additional autoimmune loci and fine mapping of such regions may provide further insight into the genetics and molecular pathophysiology of psoriasis.

AB - Background Phenotypically diverse autoimmune conditions share common genetic susceptibility loci and underlying molecular pathways.Objectives By systematically searching for single nucleotide polymorphisms (SNPs) associated with another autoimmune disease, rheumatoid arthritis (RA), we aimed to elucidate novel genetic markers of psoriasis.Methods We investigated 18 SNPs, previously confirmed as being associated with RA, in a U. K. cohort of 623 patients with early-onset psoriasis (presenting before age 40 years), comparing them with 2662 control subjects.Results Our findings confirm the association of early-onset psoriasis with REL (rs13031237, P = 0.0027). The minor allele of REL had opposing effects upon susceptibility to disease in patients with psoriasis and RA.Conclusion Similar exploration of additional autoimmune loci and fine mapping of such regions may provide further insight into the genetics and molecular pathophysiology of psoriasis.

KW - GENOME-WIDE ASSOCIATION

KW - SUSCEPTIBILITY LOCI

KW - CROHN DISEASE

U2 - 10.1111/bjd.12106

DO - 10.1111/bjd.12106

M3 - Article

C2 - 23106574

SN - 0007-0963

VL - 168

SP - 864

EP - 866

JO - British Journal of Dermatology

JF - British Journal of Dermatology

IS - 4

ER -

An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene

Abstract

Keywords

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