An Oncogenic Role for the Ubiquitin Ligase UBE2O by Targeting AMPK-α2 for Degradation

D. Grahame Hardie (Lead / Corresponding author)

Research output: Contribution to journalArticle

4 Citations (Scopus)
181 Downloads (Pure)

Abstract

There has been controversy regarding the role of AMPK in cancer, some of which may be due to functional differences between isoforms. In this issue of Cancer Cell, Vila et al. report that UBE2O, a ubiquitin ligase overexpressed in some human cancers, specifically triggers the ubiquitination and degradation of AMPK-α2.

Original languageEnglish
Pages (from-to)163-165
Number of pages3
JournalCancer Cell
Volume31
Issue number2
DOIs
Publication statusPublished - 13 Feb 2017

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