An overview of the cell cycle arrest protein, p21WAF1

K. Harada (Lead / Corresponding author), G.R. Ogden

    Research output: Contribution to journalArticlepeer-review

    86 Citations (Scopus)


    p21, also known as WAF1, Cip1, Sdi1, Mda 6 and Cap20 is a cell cycle protein that regulates and can arrest the cell cycle in G1 or S phase (either dependent or independent of p53). Its role may be pivotal in many cell processes including differentiation and apoptosis. This brief overview provides a summary of its presently known functions and indicates areas for further research, particularly in relation to oral malignant disease. Greater understanding of its role may lead to therapeutic advances in the management of malignant disease. Copyright (C) 2000 Elsevier Science Ltd.
    Original languageEnglish
    Pages (from-to)3-7
    Number of pages5
    JournalOral Oncology
    Issue number1
    Publication statusPublished - Jan 2000


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