Herpes gestationis is a blistering disease associated with pregnancy that almost invariably recurs in subsequent pregnancies.1,2 Immunologic factors have been implicated in the pathogenesis of herpes gestationis, and women with HLA-DR3 and -DR4 antigens are most at risk.3,4 Uninvolved pregnancies have been described and were thought to occur in association with a change in paternity.3 It has been suggested that an uninvolved pregnancy may occur if the fetus has the HLA-DR antigens possessed by the mother.1 We describe a patient whose first pregnancy was complicated by herpes gestationis but whose second was not, despite constant paternity and nonmatching HLA-DR antigens between mother and child.
|Number of pages||2|
|Journal||Archives of Dermatology|
|Publication status||Published - Sep 1995|
- Pemphigoid Gestationis