An uninvolved pregnancy in a patient after a previous episode of herpes gestationis

TY - JOUR

T1 - An uninvolved pregnancy in a patient after a previous episode of herpes gestationis

AU - Ibbotson, Sally H.

AU - Lawrence, C. M.

PY - 1995/9

Y1 - 1995/9

N2 - Herpes gestationis is a blistering disease associated with pregnancy that almost invariably recurs in subsequent pregnancies.1,2 Immunologic factors have been implicated in the pathogenesis of herpes gestationis, and women with HLA-DR3 and -DR4 antigens are most at risk.3,4 Uninvolved pregnancies have been described and were thought to occur in association with a change in paternity.3 It has been suggested that an uninvolved pregnancy may occur if the fetus has the HLA-DR antigens possessed by the mother.1 We describe a patient whose first pregnancy was complicated by herpes gestationis but whose second was not, despite constant paternity and nonmatching HLA-DR antigens between mother and child.

AB - Herpes gestationis is a blistering disease associated with pregnancy that almost invariably recurs in subsequent pregnancies.1,2 Immunologic factors have been implicated in the pathogenesis of herpes gestationis, and women with HLA-DR3 and -DR4 antigens are most at risk.3,4 Uninvolved pregnancies have been described and were thought to occur in association with a change in paternity.3 It has been suggested that an uninvolved pregnancy may occur if the fetus has the HLA-DR antigens possessed by the mother.1 We describe a patient whose first pregnancy was complicated by herpes gestationis but whose second was not, despite constant paternity and nonmatching HLA-DR antigens between mother and child.

KW - Pemphigoid Gestationis

KW - Humans

KW - Adult

KW - Recurrence

KW - Female

KW - Pregnancy

U2 - 10.1001/archderm.1995.01690210123027

DO - 10.1001/archderm.1995.01690210123027

M3 - Article

C2 - 7661620

SN - 0003-987X

VL - 131

SP - 1091

EP - 1092

JO - Archives of Dermatology

JF - Archives of Dermatology

IS - 9

ER -