Anabolic androgenic steroids reverse the beneficial effect of exercise on tendon biomechanics: An experimental study

Serafim Tsitsilonis; Chatzistergos E. Panagiotis; Mitousoudis S. Athanasios; Kourkoulis K. Stavros; Vlachos S. Ioannis; Agrogiannis George; Fasseas Konstantinos; Perrea N. Despina; Zoubos B. Aristides

doi:10.1016/j.fas.2013.12.001

Anabolic androgenic steroids reverse the beneficial effect of exercise on tendon biomechanics: An experimental study

Serafim Tsitsilonis (Lead / Corresponding author)
, Chatzistergos E. Panagiotis
, Mitousoudis S. Athanasios
, Kourkoulis K. Stavros
, Vlachos S. Ioannis
, Agrogiannis George
, Fasseas Konstantinos
, Perrea N. Despina
, Zoubos B. Aristides

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Background: The effect of anabolic androgenic steroids on tendons has not yet been fully elucidated. Aim of the present study was the evaluation of the impact of anabolic androgenic steroids on the biomechanical and histological characteristics of Achilles tendons. Methods: Twenty-four male Wistar rats were randomized into four groups with exercise and anabolic steroids (nandrolone decanoate) serving as variables. Protocol duration was 12 weeks. Following euthanasia, tendons' biomechanical properties were tested with the use of a modified clamping configuration. Histological examination with light and electron microscopy were also performed. Results: In the group of anabolic steroids and exercise the lowest fracture stress values were observed, while in the exercise group the highest ones. Histological examination by light and electron microscopy revealed areas of collagen dysplasia and an increased epitendon in the groups receiving anabolic steroids and exercise. Conclusions: These findings suggest that anabolic androgenic steroids reverse the beneficial effect of exercise, thus resulting in inferior maximal stress values.

Original language	English
Pages (from-to)	94-99
Number of pages	6
Journal	Foot and Ankle Surgery
Volume	20
Issue number	2
Early online date	14 Dec 2013
DOIs	https://doi.org/10.1016/j.fas.2013.12.001
Publication status	Published - Jun 2014

Keywords

Achilles tendon
Anabolic androgenic steroids
Biomechanics
Rupture

ASJC Scopus subject areas

Orthopedics and Sports Medicine

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10.1016/j.fas.2013.12.001Licence: Elsevier User Licence

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title = "Anabolic androgenic steroids reverse the beneficial effect of exercise on tendon biomechanics: An experimental study",

abstract = "Background: The effect of anabolic androgenic steroids on tendons has not yet been fully elucidated. Aim of the present study was the evaluation of the impact of anabolic androgenic steroids on the biomechanical and histological characteristics of Achilles tendons. Methods: Twenty-four male Wistar rats were randomized into four groups with exercise and anabolic steroids (nandrolone decanoate) serving as variables. Protocol duration was 12 weeks. Following euthanasia, tendons' biomechanical properties were tested with the use of a modified clamping configuration. Histological examination with light and electron microscopy were also performed. Results: In the group of anabolic steroids and exercise the lowest fracture stress values were observed, while in the exercise group the highest ones. Histological examination by light and electron microscopy revealed areas of collagen dysplasia and an increased epitendon in the groups receiving anabolic steroids and exercise. Conclusions: These findings suggest that anabolic androgenic steroids reverse the beneficial effect of exercise, thus resulting in inferior maximal stress values.",

keywords = "Achilles tendon, Anabolic androgenic steroids, Biomechanics, Rupture",

author = "Serafim Tsitsilonis and Panagiotis, \{Chatzistergos E.\} and Athanasios, \{Mitousoudis S.\} and Stavros, \{Kourkoulis K.\} and Ioannis, \{Vlachos S.\} and Agrogiannis George and Fasseas Konstantinos and Despina, \{Perrea N.\} and Aristides, \{Zoubos B.\}",

year = "2014",

month = jun,

doi = "10.1016/j.fas.2013.12.001",

language = "English",

volume = "20",

pages = "94--99",

journal = "Foot and Ankle Surgery",

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T1 - Anabolic androgenic steroids reverse the beneficial effect of exercise on tendon biomechanics

T2 - An experimental study

AU - Tsitsilonis, Serafim

AU - Panagiotis, Chatzistergos E.

AU - Athanasios, Mitousoudis S.

AU - Stavros, Kourkoulis K.

AU - Ioannis, Vlachos S.

AU - George, Agrogiannis

AU - Konstantinos, Fasseas

AU - Despina, Perrea N.

AU - Aristides, Zoubos B.

PY - 2014/6

Y1 - 2014/6

N2 - Background: The effect of anabolic androgenic steroids on tendons has not yet been fully elucidated. Aim of the present study was the evaluation of the impact of anabolic androgenic steroids on the biomechanical and histological characteristics of Achilles tendons. Methods: Twenty-four male Wistar rats were randomized into four groups with exercise and anabolic steroids (nandrolone decanoate) serving as variables. Protocol duration was 12 weeks. Following euthanasia, tendons' biomechanical properties were tested with the use of a modified clamping configuration. Histological examination with light and electron microscopy were also performed. Results: In the group of anabolic steroids and exercise the lowest fracture stress values were observed, while in the exercise group the highest ones. Histological examination by light and electron microscopy revealed areas of collagen dysplasia and an increased epitendon in the groups receiving anabolic steroids and exercise. Conclusions: These findings suggest that anabolic androgenic steroids reverse the beneficial effect of exercise, thus resulting in inferior maximal stress values.

AB - Background: The effect of anabolic androgenic steroids on tendons has not yet been fully elucidated. Aim of the present study was the evaluation of the impact of anabolic androgenic steroids on the biomechanical and histological characteristics of Achilles tendons. Methods: Twenty-four male Wistar rats were randomized into four groups with exercise and anabolic steroids (nandrolone decanoate) serving as variables. Protocol duration was 12 weeks. Following euthanasia, tendons' biomechanical properties were tested with the use of a modified clamping configuration. Histological examination with light and electron microscopy were also performed. Results: In the group of anabolic steroids and exercise the lowest fracture stress values were observed, while in the exercise group the highest ones. Histological examination by light and electron microscopy revealed areas of collagen dysplasia and an increased epitendon in the groups receiving anabolic steroids and exercise. Conclusions: These findings suggest that anabolic androgenic steroids reverse the beneficial effect of exercise, thus resulting in inferior maximal stress values.

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KW - Anabolic androgenic steroids

KW - Biomechanics

KW - Rupture

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ER -

Anabolic androgenic steroids reverse the beneficial effect of exercise on tendon biomechanics: An experimental study

Abstract

Keywords

ASJC Scopus subject areas

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Corrigendum to "Anabolic androgenic steroids reverse the beneficial effect of exercise on tendon biomechanics: An experimental study" [Foot Ankle Surg 20 (2014) 94-99]

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