ANCA-associated renal vasculitis is associated with rurality but not seasonality or deprivation in a complete national cohort study

Oshorenua Aiyegbusi (Lead / Corresponding author), Marina Frleta-Gilchrist, Jamie P. Traynor, Bruce Mackinnon, Samira Bell, Robert W. Hunter, Neeraj Dhaun, Dana Kidder, Graham Stewart, Nicola Joss, Michael Kelly, Shahzad Shah, Vishal Dey, Kate Buck, Kathryn I. Stevens, Colin C. Geddes, Emily P. McQuarrie, Scottish Renal Biopsy Registry

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)
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Background: Small studies suggest an association between ANCA-associated vasculitis (AAV) incidence and rurality, seasonality and socioeconomic deprivation. We examined the incidence of kidney biopsy-proven AAV and its relationship with these factors in the adult Scottish population.

Methods: Using the Scottish Renal Biopsy Registry, all adult native kidney biopsies performed between 2014 and 2018 with a diagnosis of granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) were identified. The Scottish Government Urban Rural Classification was used for rurality analysis. Seasons were defined as autumn (September-November), winter (December-February), spring (March-May) and summer (June-August). Patients were separated into quintiles of socioeconomic deprivation using the validated Scottish Index of Multiple Deprivation and incidence standardised to age. Estimated glomerular filtration rate and urine protein:creatinine ratio at time of biopsy were used to assess disease severity.

Results: 339 cases of renal AAV were identified, of which 62% had MPA and 38% had GPA diagnosis. AAV incidence was 15.1 per million population per year (pmp/year). Mean age was 66 years and 54% were female. Incidence of GPA (but not MPA) was positively associated with rurality (5.2, 8.4 and 9.1 pmp/year in 'urban', 'accessible remote' and 'rural remote' areas, respectively; p=0.04). The age-standardised incidence ratio was similar across all quintiles of deprivation (p=ns).

Conclusions: Seasonality and disease severity did not vary across AAV study groups. In this complete national cohort study, we observed a positive association between kidney biopsy-proven GPA and rurality.

Original languageEnglish
Article numbere001555
Number of pages8
JournalRMD Open
Issue number2
Early online date19 Apr 2021
Publication statusPublished - 19 Apr 2021


  • autoimmune diseases
  • epidemiology
  • granulomatosis with polyangiitis
  • immune system diseases
  • systemic vasculitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology


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