Abstract
Generation of GTP-bound Ran on chromatin by its guanine nucleotide-exchange factor RCC1 provides a spatial signal that controls nuclear-envelope formation, nucleo-cytoplasmic transport and mitotic spindle assembly. A study now identifies an unusual post-translational modification, α-N-methylation of the amino-terminal tail of RCC1, which anchors the protein on chromosomes.
Original language | English |
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Pages (from-to) | 485-487 |
Number of pages | 3 |
Journal | Nature Cell Biology |
Volume | 9 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 May 2007 |
ASJC Scopus subject areas
- Cell Biology