Anchoring RCC1 by the tail

Paul R. Clarke (Lead / Corresponding author)

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Generation of GTP-bound Ran on chromatin by its guanine nucleotide-exchange factor RCC1 provides a spatial signal that controls nuclear-envelope formation, nucleo-cytoplasmic transport and mitotic spindle assembly. A study now identifies an unusual post-translational modification, α-N-methylation of the amino-terminal tail of RCC1, which anchors the protein on chromosomes.

Original languageEnglish
Pages (from-to)485-487
Number of pages3
JournalNature Cell Biology
Volume9
Issue number5
DOIs
Publication statusPublished - 1 May 2007

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Guanine Nucleotide Exchange Factors
Spindle Apparatus
Cell Nucleus Active Transport
Nuclear Envelope
Post Translational Protein Processing
Guanosine Triphosphate
Methylation
Chromatin
Chromosomes
Proteins

Cite this

Clarke, Paul R. / Anchoring RCC1 by the tail. In: Nature Cell Biology. 2007 ; Vol. 9, No. 5. pp. 485-487.
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Anchoring RCC1 by the tail. / Clarke, Paul R. (Lead / Corresponding author).

In: Nature Cell Biology, Vol. 9, No. 5, 01.05.2007, p. 485-487.

Research output: Contribution to journalArticle

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