Anchoring RCC1 by the tail

Paul R. Clarke (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    Generation of GTP-bound Ran on chromatin by its guanine nucleotide-exchange factor RCC1 provides a spatial signal that controls nuclear-envelope formation, nucleo-cytoplasmic transport and mitotic spindle assembly. A study now identifies an unusual post-translational modification, α-N-methylation of the amino-terminal tail of RCC1, which anchors the protein on chromosomes.

    Original languageEnglish
    Pages (from-to)485-487
    Number of pages3
    JournalNature Cell Biology
    Volume9
    Issue number5
    DOIs
    Publication statusPublished - 1 May 2007

    ASJC Scopus subject areas

    • Cell Biology

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