Anchoring RCC1 by the tail

Paul R. Clarke (Lead / Corresponding author)

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Generation of GTP-bound Ran on chromatin by its guanine nucleotide-exchange factor RCC1 provides a spatial signal that controls nuclear-envelope formation, nucleo-cytoplasmic transport and mitotic spindle assembly. A study now identifies an unusual post-translational modification, α-N-methylation of the amino-terminal tail of RCC1, which anchors the protein on chromosomes.

Original languageEnglish
Pages (from-to)485-487
Number of pages3
JournalNature Cell Biology
Volume9
Issue number5
DOIs
Publication statusPublished - 1 May 2007

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