Anchoring RCC1 by the tail

Paul R. Clarke

doi:10.1038/ncb0507-485

Anchoring RCC1 by the tail

Paul R. Clarke (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Generation of GTP-bound Ran on chromatin by its guanine nucleotide-exchange factor RCC1 provides a spatial signal that controls nuclear-envelope formation, nucleo-cytoplasmic transport and mitotic spindle assembly. A study now identifies an unusual post-translational modification, α-N-methylation of the amino-terminal tail of RCC1, which anchors the protein on chromosomes.

Original language	English
Pages (from-to)	485-487
Number of pages	3
Journal	Nature Cell Biology
Volume	9
Issue number	5
DOIs	https://doi.org/10.1038/ncb0507-485
Publication status	Published - 1 May 2007

ASJC Scopus subject areas

Cell Biology

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10.1038/ncb0507-485

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title = "Anchoring RCC1 by the tail",

abstract = "Generation of GTP-bound Ran on chromatin by its guanine nucleotide-exchange factor RCC1 provides a spatial signal that controls nuclear-envelope formation, nucleo-cytoplasmic transport and mitotic spindle assembly. A study now identifies an unusual post-translational modification, α-N-methylation of the amino-terminal tail of RCC1, which anchors the protein on chromosomes.",

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AB - Generation of GTP-bound Ran on chromatin by its guanine nucleotide-exchange factor RCC1 provides a spatial signal that controls nuclear-envelope formation, nucleo-cytoplasmic transport and mitotic spindle assembly. A study now identifies an unusual post-translational modification, α-N-methylation of the amino-terminal tail of RCC1, which anchors the protein on chromosomes.

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DO - 10.1038/ncb0507-485

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JO - Nature Cell Biology

JF - Nature Cell Biology

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ER -

Anchoring RCC1 by the tail

Abstract

ASJC Scopus subject areas

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