Animal models of bone cancer pain

systematic review and meta-analyses

Gillian L. Currie, Ada Delaney, Michael I. Bennett, Anthony H. Dickenson, Kieren J. Egan, Hanna M Vesterinen, Emily S. Sena, Malcolm R. Macleod (Lead / Corresponding author), Lesley A. Colvin, Marie T. Fallon

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Pain can significantly decrease the quality of life of patients with advanced cancer. Current treatment strategies often provide inadequate analgesia and unacceptable side effects. Animal models of bone cancer pain are used in the development of novel pharmacological approaches. Here we conducted a systematic review and meta-analysis of publications describing in vivo modelling of bone cancer pain in which behavioural, general health, macroscopic, histological, biochemical, or electrophysiological outcomes were reported and compared to appropriate controls. In all, 150 publications met our inclusion criteria, describing 38 different models of bone cancer pain. Reported methodological quality was low; only 31% of publications reported blinded assessment of outcome, and 11% reported random allocation to group. No publication reported a sample size calculation. Studies that reported measures to reduce bias reported smaller differences in behavioural outcomes between tumour-bearing and control animals, and studies that presented a statement regarding a conflict of interest reported larger differences in behavioural outcomes. Larger differences in behavioural outcomes were reported in female animals, when cancer cells were injected into either the tibia or femur, and when MatLyLu prostate or Lewis Lung cancer cells were used. Mechanical-evoked pain behaviours were most commonly reported; however, the largest difference was observed in spontaneous pain behaviours. In the spinal cord astrocyte activation and increased levels of Substance P receptor internalisation, c-Fos, dynorphin, tumor necrosis factor-α and interleukin-1β have been reported in bone cancer pain models, suggesting several potential therapeutic targets. However, the translational impact of animal models on clinical pain research could be enhanced by improving methodological quality.
Original languageEnglish
Pages (from-to)917-926
Number of pages10
JournalPain
Volume154
Issue number6
DOIs
Publication statusPublished - Jun 2013

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Bone Neoplasms
Publications
Meta-Analysis
Animal Models
Pain
Neurokinin-1 Receptors
Dynorphins
Conflict of Interest
Neoplasms
Random Allocation
Tibia
Interleukin-1
Astrocytes
Sample Size
Femur
Analgesia
Prostate
Lung Neoplasms
Spinal Cord
Tumor Necrosis Factor-alpha

Cite this

Currie, G. L., Delaney, A., Bennett, M. I., Dickenson, A. H., Egan, K. J., Vesterinen, H. M., ... Fallon, M. T. (2013). Animal models of bone cancer pain: systematic review and meta-analyses. Pain, 154(6), 917-926. https://doi.org/10.1016/j.pain.2013.02.033
Currie, Gillian L. ; Delaney, Ada ; Bennett, Michael I. ; Dickenson, Anthony H. ; Egan, Kieren J. ; Vesterinen, Hanna M ; Sena, Emily S. ; Macleod, Malcolm R. ; Colvin, Lesley A. ; Fallon, Marie T. / Animal models of bone cancer pain : systematic review and meta-analyses. In: Pain. 2013 ; Vol. 154, No. 6. pp. 917-926.
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Currie, GL, Delaney, A, Bennett, MI, Dickenson, AH, Egan, KJ, Vesterinen, HM, Sena, ES, Macleod, MR, Colvin, LA & Fallon, MT 2013, 'Animal models of bone cancer pain: systematic review and meta-analyses', Pain, vol. 154, no. 6, pp. 917-926. https://doi.org/10.1016/j.pain.2013.02.033

Animal models of bone cancer pain : systematic review and meta-analyses. / Currie, Gillian L.; Delaney, Ada; Bennett, Michael I.; Dickenson, Anthony H.; Egan, Kieren J.; Vesterinen, Hanna M; Sena, Emily S.; Macleod, Malcolm R. (Lead / Corresponding author); Colvin, Lesley A.; Fallon, Marie T.

In: Pain, Vol. 154, No. 6, 06.2013, p. 917-926.

Research output: Contribution to journalArticle

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T1 - Animal models of bone cancer pain

T2 - systematic review and meta-analyses

AU - Currie, Gillian L.

AU - Delaney, Ada

AU - Bennett, Michael I.

AU - Dickenson, Anthony H.

AU - Egan, Kieren J.

AU - Vesterinen, Hanna M

AU - Sena, Emily S.

AU - Macleod, Malcolm R.

AU - Colvin, Lesley A.

AU - Fallon, Marie T.

N1 - Copyright © 2013. Published by Elsevier B.V.

PY - 2013/6

Y1 - 2013/6

N2 - Pain can significantly decrease the quality of life of patients with advanced cancer. Current treatment strategies often provide inadequate analgesia and unacceptable side effects. Animal models of bone cancer pain are used in the development of novel pharmacological approaches. Here we conducted a systematic review and meta-analysis of publications describing in vivo modelling of bone cancer pain in which behavioural, general health, macroscopic, histological, biochemical, or electrophysiological outcomes were reported and compared to appropriate controls. In all, 150 publications met our inclusion criteria, describing 38 different models of bone cancer pain. Reported methodological quality was low; only 31% of publications reported blinded assessment of outcome, and 11% reported random allocation to group. No publication reported a sample size calculation. Studies that reported measures to reduce bias reported smaller differences in behavioural outcomes between tumour-bearing and control animals, and studies that presented a statement regarding a conflict of interest reported larger differences in behavioural outcomes. Larger differences in behavioural outcomes were reported in female animals, when cancer cells were injected into either the tibia or femur, and when MatLyLu prostate or Lewis Lung cancer cells were used. Mechanical-evoked pain behaviours were most commonly reported; however, the largest difference was observed in spontaneous pain behaviours. In the spinal cord astrocyte activation and increased levels of Substance P receptor internalisation, c-Fos, dynorphin, tumor necrosis factor-α and interleukin-1β have been reported in bone cancer pain models, suggesting several potential therapeutic targets. However, the translational impact of animal models on clinical pain research could be enhanced by improving methodological quality.

AB - Pain can significantly decrease the quality of life of patients with advanced cancer. Current treatment strategies often provide inadequate analgesia and unacceptable side effects. Animal models of bone cancer pain are used in the development of novel pharmacological approaches. Here we conducted a systematic review and meta-analysis of publications describing in vivo modelling of bone cancer pain in which behavioural, general health, macroscopic, histological, biochemical, or electrophysiological outcomes were reported and compared to appropriate controls. In all, 150 publications met our inclusion criteria, describing 38 different models of bone cancer pain. Reported methodological quality was low; only 31% of publications reported blinded assessment of outcome, and 11% reported random allocation to group. No publication reported a sample size calculation. Studies that reported measures to reduce bias reported smaller differences in behavioural outcomes between tumour-bearing and control animals, and studies that presented a statement regarding a conflict of interest reported larger differences in behavioural outcomes. Larger differences in behavioural outcomes were reported in female animals, when cancer cells were injected into either the tibia or femur, and when MatLyLu prostate or Lewis Lung cancer cells were used. Mechanical-evoked pain behaviours were most commonly reported; however, the largest difference was observed in spontaneous pain behaviours. In the spinal cord astrocyte activation and increased levels of Substance P receptor internalisation, c-Fos, dynorphin, tumor necrosis factor-α and interleukin-1β have been reported in bone cancer pain models, suggesting several potential therapeutic targets. However, the translational impact of animal models on clinical pain research could be enhanced by improving methodological quality.

U2 - 10.1016/j.pain.2013.02.033

DO - 10.1016/j.pain.2013.02.033

M3 - Article

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SP - 917

EP - 926

JO - Pain

JF - Pain

SN - 0304-3959

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Currie GL, Delaney A, Bennett MI, Dickenson AH, Egan KJ, Vesterinen HM et al. Animal models of bone cancer pain: systematic review and meta-analyses. Pain. 2013 Jun;154(6):917-926. https://doi.org/10.1016/j.pain.2013.02.033