Projects per year
Abstract
The WHO recognizes human African trypanosomiasis, Chagas disease and the leishmaniases as neglected tropical diseases. These diseases are caused by parasitic trypanosomatids and range in severity from mild and self-curing to near invariably fatal. Public health advances have substantially decreased the effect of these diseases in recent decades but alone will not eliminate them. In this Review, we discuss why new drugs against trypanosomatids are required, approaches that are under investigation to develop new drugs and why the drug discovery pipeline remains essentially unfilled. In addition, we consider the important challenges to drug discovery strategies and the new technologies that can address them. The combination of new drugs, new technologies and public health initiatives is essential for the management, and hopefully eventual elimination, of trypanosomatid diseases from the human population.
Original language | English |
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Pages (from-to) | 217-231 |
Number of pages | 15 |
Journal | Nature Reviews Microbiology |
Volume | 15 |
Issue number | 4 |
Early online date | 27 Feb 2017 |
DOIs | |
Publication status | Published - Apr 2017 |
Keywords
- Antiparasitic agents
- Drug development
- Parasite biology
- Parasitic infection
Fingerprint
Dive into the research topics of 'Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need'. Together they form a unique fingerprint.Projects
- 10 Finished
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A Systems Approach for Understanding Cell Surface Dynamics in Trypanosomes (Investigator Award)
Field, M. (Investigator)
1/10/17 → 31/03/24
Project: Research
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Global Mechanisms for Control of the Trypanosome Proteome: Defining the Composition, Origins and Roles of Cullin E3 Ligases
Field, M. (Investigator)
1/01/17 → 31/12/19
Project: Research
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Chemical Biology: Leveraging Phenotypic Hits Against Kinetoplastids (Strategic Grant)
Fairlamb, A. (Investigator), Field, M. (Investigator), Gilbert, I. (Investigator), Gray, D. (Investigator), Horn, D. (Investigator) & Wyatt, P. (Investigator)
1/01/15 → 31/12/20
Project: Research
Research output
- 311 Citations
- 2 Comment/debate
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Erratum to: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need (Nature Reviews Microbiology, (2017), 15, 4, (217-231), 10.1038/nrmicro.2016.193)
Field, M. C., Horn, D., Fairlamb, A. H., Ferguson, M. A. J., Gray, D. W., Read, K. D., De Rycker, M., Torrie, L. S., Wyatt, P. G., Wyllie, S. & Gilbert, I. H., 1 Nov 2018, In: Nature Reviews Microbiology. 16, 11, 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Erratum: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
Field, M. C., Horn, D., Fairlamb, A., Ferguson, M., Gray, D., Read, K., De Rycker, M., Torrie, L., Wyatt, P., Wyllie, S. & Gilbert, I. H., 5 Jun 2017, In: Nature Reviews Microbiology. 15, 1 p., 447.Research output: Contribution to journal › Comment/debate › peer-review
Open Access1 Citation (Scopus)