Antibiotic prophylaxis is ineffective in preventing pneumonia post-stroke

N. Rae (Lead / Corresponding author), J. D. Chalmers

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)


    STROKE-INF aimed to evaluate whether prophylactic
    antibiotics could prevent the development of pneumonia
    in patients with dysphagia after acute stroke. The study
    was a prospective cluster-randomised open-label
    controlled trial. Patients were enrolled within 48 hours
    of stroke onset. In total, 48 stroke units across the UK
    were randomly assigned to deliver standard stroke unit
    care with prophylactic antibiotics or standard stroke
    unit care alone. The antibiotic regimens were left to the
    discretion of the investigators but largely consisted of a
    β-lactam (amoxicillin or co-amoxiclav) with or without
    clarithromycin. The primary outcome measure was the
    development of pneumonia in the first 14 days, defined
    using a criteria-based algorithm and also as diagnosed by
    a physician. Suspected infections could be treated with
    additional antibiotics.
    Original languageEnglish
    Pages (from-to)276-277
    Number of pages2
    JournalJournal of the Royal College of Physicians of Edinburgh
    Issue number4
    Publication statusPublished - 2015


    • Antibiotic prophylaxis
    • Deglutition disorders
    • Female
    • Humans
    • Male
    • Pneumonia, Aspiration
    • Stroke
    • Comment
    • Journal article


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