Antibiotics and antibiotic resistance genes in global lakes: A review and meta-analysis

Yuyi Yang (Lead / Corresponding author), Wenjuan Song, Hui Lin, Weibo Wang, Linna Du, Wei Xing (Lead / Corresponding author)

Research output: Contribution to journalReview article

47 Citations (Scopus)
181 Downloads (Pure)

Abstract

Lakes are an important source of freshwater, containing nearly 90% of the liquid surface fresh water worldwide. Long retention times in lakes mean pollutants from discharges slowly circulate around the lakes and may lead to high ecological risk for ecosystem and human health. In recent decades, antibiotics and antibiotic resistance genes (ARGs) have been regarded as emerging pollutants. The occurrence and distribution of antibiotics and ARGs in global freshwater lakes are summarized to show the pollution level of antibiotics and ARGs and to identify some of the potential risks to ecosystem and human health. Fifty-seven antibiotics were reported at least once in the studied lakes. Our meta-analysis shows that sulfamethoxazole, sulfamerazine, sulfameter, tetracycline, oxytetracycline, erythromycin, and roxithromycin were found at high concentrations in both lake water and lake sediment. There is no significant difference in the concentration of sulfonamides in lake water from China and that from other countries worldwide; however, there was a significant difference in quinolones. Erythromycin had the lowest predicted hazardous concentration for 5% of the species (HC5) and the highest ecological risk in lakes. There was no significant difference in the concentration of sulfonamide resistance genes (sul1 and sul2) in lake water and river water. There is surprisingly limited research on the role of aquatic biota in propagation of ARGs in freshwater lakes. As an environment that is susceptible to cumulative build-up of pollutants, lakes provide an important environment to study the fate of antibiotics and transport of ARGs with a broad range of niches including bacterial community, aquatic plants and animals.

Original languageEnglish
Pages (from-to)60-73
Number of pages14
JournalEnvironment International
Volume116
Early online date10 Apr 2018
DOIs
Publication statusPublished - Jul 2018

Fingerprint

antibiotic resistance
meta-analysis
antibiotics
gene
lake
lake water
ecosystem health
pollutant
oxytetracycline
aquatic plant
lacustrine deposit
river water
biota
niche
surface water
pollution
liquid

Keywords

  • Antibiotic resistance genes
  • Antibiotics
  • Aquatic biota
  • Meta-analysis
  • Niche
  • Species sensitivity distributions

Cite this

Yang, Yuyi ; Song, Wenjuan ; Lin, Hui ; Wang, Weibo ; Du, Linna ; Xing, Wei. / Antibiotics and antibiotic resistance genes in global lakes : A review and meta-analysis. In: Environment International. 2018 ; Vol. 116. pp. 60-73.
@article{509db54950c64047b48d420c28b27438,
title = "Antibiotics and antibiotic resistance genes in global lakes: A review and meta-analysis",
abstract = "Lakes are an important source of freshwater, containing nearly 90{\%} of the liquid surface fresh water worldwide. Long retention times in lakes mean pollutants from discharges slowly circulate around the lakes and may lead to high ecological risk for ecosystem and human health. In recent decades, antibiotics and antibiotic resistance genes (ARGs) have been regarded as emerging pollutants. The occurrence and distribution of antibiotics and ARGs in global freshwater lakes are summarized to show the pollution level of antibiotics and ARGs and to identify some of the potential risks to ecosystem and human health. Fifty-seven antibiotics were reported at least once in the studied lakes. Our meta-analysis shows that sulfamethoxazole, sulfamerazine, sulfameter, tetracycline, oxytetracycline, erythromycin, and roxithromycin were found at high concentrations in both lake water and lake sediment. There is no significant difference in the concentration of sulfonamides in lake water from China and that from other countries worldwide; however, there was a significant difference in quinolones. Erythromycin had the lowest predicted hazardous concentration for 5{\%} of the species (HC5) and the highest ecological risk in lakes. There was no significant difference in the concentration of sulfonamide resistance genes (sul1 and sul2) in lake water and river water. There is surprisingly limited research on the role of aquatic biota in propagation of ARGs in freshwater lakes. As an environment that is susceptible to cumulative build-up of pollutants, lakes provide an important environment to study the fate of antibiotics and transport of ARGs with a broad range of niches including bacterial community, aquatic plants and animals.",
keywords = "Antibiotic resistance genes, Antibiotics, Aquatic biota, Meta-analysis, Niche, Species sensitivity distributions",
author = "Yuyi Yang and Wenjuan Song and Hui Lin and Weibo Wang and Linna Du and Wei Xing",
note = "This project was supported in part by National Natural Science Foundation of China [grant number 31400113, 31370479], Youth Innovation Promotion Association of Chinese Academy of Sciences [grant number 2015282], Wenzhou Science and Technology Major Project [grant number 2016N0031], Basic Public Welfare Research Projects in Zhejiang Province [grant number LGF18E090007], and State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control [grant number 2010DS700124-ZZ1802].",
year = "2018",
month = "7",
doi = "10.1016/j.envint.2018.04.011",
language = "English",
volume = "116",
pages = "60--73",
journal = "Environment International",
issn = "0160-4120",
publisher = "Elsevier BV",

}

Antibiotics and antibiotic resistance genes in global lakes : A review and meta-analysis. / Yang, Yuyi (Lead / Corresponding author); Song, Wenjuan; Lin, Hui; Wang, Weibo; Du, Linna; Xing, Wei (Lead / Corresponding author).

In: Environment International, Vol. 116, 07.2018, p. 60-73.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Antibiotics and antibiotic resistance genes in global lakes

T2 - A review and meta-analysis

AU - Yang, Yuyi

AU - Song, Wenjuan

AU - Lin, Hui

AU - Wang, Weibo

AU - Du, Linna

AU - Xing, Wei

N1 - This project was supported in part by National Natural Science Foundation of China [grant number 31400113, 31370479], Youth Innovation Promotion Association of Chinese Academy of Sciences [grant number 2015282], Wenzhou Science and Technology Major Project [grant number 2016N0031], Basic Public Welfare Research Projects in Zhejiang Province [grant number LGF18E090007], and State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control [grant number 2010DS700124-ZZ1802].

PY - 2018/7

Y1 - 2018/7

N2 - Lakes are an important source of freshwater, containing nearly 90% of the liquid surface fresh water worldwide. Long retention times in lakes mean pollutants from discharges slowly circulate around the lakes and may lead to high ecological risk for ecosystem and human health. In recent decades, antibiotics and antibiotic resistance genes (ARGs) have been regarded as emerging pollutants. The occurrence and distribution of antibiotics and ARGs in global freshwater lakes are summarized to show the pollution level of antibiotics and ARGs and to identify some of the potential risks to ecosystem and human health. Fifty-seven antibiotics were reported at least once in the studied lakes. Our meta-analysis shows that sulfamethoxazole, sulfamerazine, sulfameter, tetracycline, oxytetracycline, erythromycin, and roxithromycin were found at high concentrations in both lake water and lake sediment. There is no significant difference in the concentration of sulfonamides in lake water from China and that from other countries worldwide; however, there was a significant difference in quinolones. Erythromycin had the lowest predicted hazardous concentration for 5% of the species (HC5) and the highest ecological risk in lakes. There was no significant difference in the concentration of sulfonamide resistance genes (sul1 and sul2) in lake water and river water. There is surprisingly limited research on the role of aquatic biota in propagation of ARGs in freshwater lakes. As an environment that is susceptible to cumulative build-up of pollutants, lakes provide an important environment to study the fate of antibiotics and transport of ARGs with a broad range of niches including bacterial community, aquatic plants and animals.

AB - Lakes are an important source of freshwater, containing nearly 90% of the liquid surface fresh water worldwide. Long retention times in lakes mean pollutants from discharges slowly circulate around the lakes and may lead to high ecological risk for ecosystem and human health. In recent decades, antibiotics and antibiotic resistance genes (ARGs) have been regarded as emerging pollutants. The occurrence and distribution of antibiotics and ARGs in global freshwater lakes are summarized to show the pollution level of antibiotics and ARGs and to identify some of the potential risks to ecosystem and human health. Fifty-seven antibiotics were reported at least once in the studied lakes. Our meta-analysis shows that sulfamethoxazole, sulfamerazine, sulfameter, tetracycline, oxytetracycline, erythromycin, and roxithromycin were found at high concentrations in both lake water and lake sediment. There is no significant difference in the concentration of sulfonamides in lake water from China and that from other countries worldwide; however, there was a significant difference in quinolones. Erythromycin had the lowest predicted hazardous concentration for 5% of the species (HC5) and the highest ecological risk in lakes. There was no significant difference in the concentration of sulfonamide resistance genes (sul1 and sul2) in lake water and river water. There is surprisingly limited research on the role of aquatic biota in propagation of ARGs in freshwater lakes. As an environment that is susceptible to cumulative build-up of pollutants, lakes provide an important environment to study the fate of antibiotics and transport of ARGs with a broad range of niches including bacterial community, aquatic plants and animals.

KW - Antibiotic resistance genes

KW - Antibiotics

KW - Aquatic biota

KW - Meta-analysis

KW - Niche

KW - Species sensitivity distributions

U2 - 10.1016/j.envint.2018.04.011

DO - 10.1016/j.envint.2018.04.011

M3 - Review article

C2 - 29653401

VL - 116

SP - 60

EP - 73

JO - Environment International

JF - Environment International

SN - 0160-4120

ER -