Anticipating bipedalism: trabecular organization in the newborn ilium

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Abstract

    Trabecular bone structural organization is considered to be predominantly influenced by localized temporal forces which act to maintain and remodel the trabecular architecture into a biomechanically optimal configuration. In the adult pelvis, the most significant remodelling forces are believed to be those generated during bipedal locomotion. However, during the fetal and neonatal period the pelvic complex is non-weight bearing and, as such, structural organization of iliac trabecular bone cannot reflect direct stance-related forces. In this study, micro-computed tomography scans from 28 neonatal ilia were analysed, using a whole bone approach, to investigate the trabecular characteristics present within specific volumes of interest relevant to density gradients highlighted in a previous radiographic study. Analysis of the structural indices bone volume fraction, trabecular thickness, trabecular spacing and trabecular number was carried out to quantitatively investigate structural composition. Quantification of the neonatal trabecular structure reinforced radiographic observations by highlighting regions of significant architectural form which grossly parallel architectural differences in the adult pattern but which have previously been attributed to stance-related forces. It is suggested that the seemingly organized rudimentary scaffold observed in the neonatal ilium may be attributable to other non-weight bearing anatomical interactions or even to a predetermined genetic blueprint. It must also be postulated that whilst the observed patterning may be indicative of a predetermined inherent template, early non-weight bearing and late stance-related locomotive influences may subsequently be superimposed upon this scaffolding and perhaps reinforced and likely remodelled at a later age. Ultimately, the analysis of this fundamental primary pattern has core implications for understanding the earliest changes in pelvic trabecular architecture and provides a baseline insight into future ontogenetic development and bipedal capabilities.

    Original languageEnglish
    Pages (from-to)817-829
    Number of pages13
    JournalJournal of Anatomy
    Volume214
    Issue number6
    DOIs
    Publication statusPublished - Jun 2009

    Keywords

    • trabecular architecture
    • quantitative analysis
    • ilium
    • juvenile
    • micro-computed tomography
    • MICRO-COMPUTED TOMOGRAPHY
    • HUMAN CANCELLOUS BONE
    • AGE-RELATED-CHANGES
    • HUMAN GROWTH-PLATE
    • HISTOLOGICAL SECTIONS
    • ILIAC CREST
    • MECHANICAL-PROPERTIES
    • MORPHOMETRIC-ANALYSIS
    • OVARIECTOMIZED RATS
    • SACROILIAC JOINT

    Cite this

    @article{8ffb94a66c8948289c7480ef1f9bcc3f,
    title = "Anticipating bipedalism: trabecular organization in the newborn ilium",
    abstract = "Trabecular bone structural organization is considered to be predominantly influenced by localized temporal forces which act to maintain and remodel the trabecular architecture into a biomechanically optimal configuration. In the adult pelvis, the most significant remodelling forces are believed to be those generated during bipedal locomotion. However, during the fetal and neonatal period the pelvic complex is non-weight bearing and, as such, structural organization of iliac trabecular bone cannot reflect direct stance-related forces. In this study, micro-computed tomography scans from 28 neonatal ilia were analysed, using a whole bone approach, to investigate the trabecular characteristics present within specific volumes of interest relevant to density gradients highlighted in a previous radiographic study. Analysis of the structural indices bone volume fraction, trabecular thickness, trabecular spacing and trabecular number was carried out to quantitatively investigate structural composition. Quantification of the neonatal trabecular structure reinforced radiographic observations by highlighting regions of significant architectural form which grossly parallel architectural differences in the adult pattern but which have previously been attributed to stance-related forces. It is suggested that the seemingly organized rudimentary scaffold observed in the neonatal ilium may be attributable to other non-weight bearing anatomical interactions or even to a predetermined genetic blueprint. It must also be postulated that whilst the observed patterning may be indicative of a predetermined inherent template, early non-weight bearing and late stance-related locomotive influences may subsequently be superimposed upon this scaffolding and perhaps reinforced and likely remodelled at a later age. Ultimately, the analysis of this fundamental primary pattern has core implications for understanding the earliest changes in pelvic trabecular architecture and provides a baseline insight into future ontogenetic development and bipedal capabilities.",
    keywords = "trabecular architecture, quantitative analysis, ilium, juvenile, micro-computed tomography, MICRO-COMPUTED TOMOGRAPHY, HUMAN CANCELLOUS BONE, AGE-RELATED-CHANGES, HUMAN GROWTH-PLATE, HISTOLOGICAL SECTIONS, ILIAC CREST, MECHANICAL-PROPERTIES, MORPHOMETRIC-ANALYSIS, OVARIECTOMIZED RATS, SACROILIAC JOINT",
    author = "Cunningham, {Craig A.} and Black, {Sue M.}",
    year = "2009",
    month = "6",
    doi = "10.1111/j.1469-7580.2009.01073.x",
    language = "English",
    volume = "214",
    pages = "817--829",
    journal = "Journal of Anatomy",
    issn = "0021-8782",
    publisher = "Wiley",
    number = "6",

    }

    Anticipating bipedalism : trabecular organization in the newborn ilium. / Cunningham, Craig A.; Black, Sue M.

    In: Journal of Anatomy, Vol. 214, No. 6, 06.2009, p. 817-829.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Anticipating bipedalism

    T2 - trabecular organization in the newborn ilium

    AU - Cunningham, Craig A.

    AU - Black, Sue M.

    PY - 2009/6

    Y1 - 2009/6

    N2 - Trabecular bone structural organization is considered to be predominantly influenced by localized temporal forces which act to maintain and remodel the trabecular architecture into a biomechanically optimal configuration. In the adult pelvis, the most significant remodelling forces are believed to be those generated during bipedal locomotion. However, during the fetal and neonatal period the pelvic complex is non-weight bearing and, as such, structural organization of iliac trabecular bone cannot reflect direct stance-related forces. In this study, micro-computed tomography scans from 28 neonatal ilia were analysed, using a whole bone approach, to investigate the trabecular characteristics present within specific volumes of interest relevant to density gradients highlighted in a previous radiographic study. Analysis of the structural indices bone volume fraction, trabecular thickness, trabecular spacing and trabecular number was carried out to quantitatively investigate structural composition. Quantification of the neonatal trabecular structure reinforced radiographic observations by highlighting regions of significant architectural form which grossly parallel architectural differences in the adult pattern but which have previously been attributed to stance-related forces. It is suggested that the seemingly organized rudimentary scaffold observed in the neonatal ilium may be attributable to other non-weight bearing anatomical interactions or even to a predetermined genetic blueprint. It must also be postulated that whilst the observed patterning may be indicative of a predetermined inherent template, early non-weight bearing and late stance-related locomotive influences may subsequently be superimposed upon this scaffolding and perhaps reinforced and likely remodelled at a later age. Ultimately, the analysis of this fundamental primary pattern has core implications for understanding the earliest changes in pelvic trabecular architecture and provides a baseline insight into future ontogenetic development and bipedal capabilities.

    AB - Trabecular bone structural organization is considered to be predominantly influenced by localized temporal forces which act to maintain and remodel the trabecular architecture into a biomechanically optimal configuration. In the adult pelvis, the most significant remodelling forces are believed to be those generated during bipedal locomotion. However, during the fetal and neonatal period the pelvic complex is non-weight bearing and, as such, structural organization of iliac trabecular bone cannot reflect direct stance-related forces. In this study, micro-computed tomography scans from 28 neonatal ilia were analysed, using a whole bone approach, to investigate the trabecular characteristics present within specific volumes of interest relevant to density gradients highlighted in a previous radiographic study. Analysis of the structural indices bone volume fraction, trabecular thickness, trabecular spacing and trabecular number was carried out to quantitatively investigate structural composition. Quantification of the neonatal trabecular structure reinforced radiographic observations by highlighting regions of significant architectural form which grossly parallel architectural differences in the adult pattern but which have previously been attributed to stance-related forces. It is suggested that the seemingly organized rudimentary scaffold observed in the neonatal ilium may be attributable to other non-weight bearing anatomical interactions or even to a predetermined genetic blueprint. It must also be postulated that whilst the observed patterning may be indicative of a predetermined inherent template, early non-weight bearing and late stance-related locomotive influences may subsequently be superimposed upon this scaffolding and perhaps reinforced and likely remodelled at a later age. Ultimately, the analysis of this fundamental primary pattern has core implications for understanding the earliest changes in pelvic trabecular architecture and provides a baseline insight into future ontogenetic development and bipedal capabilities.

    KW - trabecular architecture

    KW - quantitative analysis

    KW - ilium

    KW - juvenile

    KW - micro-computed tomography

    KW - MICRO-COMPUTED TOMOGRAPHY

    KW - HUMAN CANCELLOUS BONE

    KW - AGE-RELATED-CHANGES

    KW - HUMAN GROWTH-PLATE

    KW - HISTOLOGICAL SECTIONS

    KW - ILIAC CREST

    KW - MECHANICAL-PROPERTIES

    KW - MORPHOMETRIC-ANALYSIS

    KW - OVARIECTOMIZED RATS

    KW - SACROILIAC JOINT

    U2 - 10.1111/j.1469-7580.2009.01073.x

    DO - 10.1111/j.1469-7580.2009.01073.x

    M3 - Article

    VL - 214

    SP - 817

    EP - 829

    JO - Journal of Anatomy

    JF - Journal of Anatomy

    SN - 0021-8782

    IS - 6

    ER -