TY - JOUR
T1 - Antigen-presenting cells in the skin and placenta in pemphigoid gestationis
AU - Kelly, S. E.
AU - Black, M. M.
AU - Fleming, S.
PY - 1990
Y1 - 1990
N2 - In pemphigoid gestationis (PG), one of the major initiating events is the aberrant expression of the class II molecules of the major histocompatibility complex in the placenta. We used a panel of 13 monoclonal antibodies to investigate the phenotype of the MHC class II positive antigen-presenting cells (APC) in the skin and placenta in PG. In the skin, the APC show reactivity with a variety of macrophage markers and the CDI marker of Langerhans cells. By contrast, the MHC class II positive cells in the placenta showed no reactivity with macrophage or Langerhans cell markers, but were the cytokeratin-positive trophoblast or vimentin-positive stromal cells.
AB - In pemphigoid gestationis (PG), one of the major initiating events is the aberrant expression of the class II molecules of the major histocompatibility complex in the placenta. We used a panel of 13 monoclonal antibodies to investigate the phenotype of the MHC class II positive antigen-presenting cells (APC) in the skin and placenta in PG. In the skin, the APC show reactivity with a variety of macrophage markers and the CDI marker of Langerhans cells. By contrast, the MHC class II positive cells in the placenta showed no reactivity with macrophage or Langerhans cell markers, but were the cytokeratin-positive trophoblast or vimentin-positive stromal cells.
U2 - 10.1111/j.1365-2133.1990.tb07280.x
DO - 10.1111/j.1365-2133.1990.tb07280.x
M3 - Article
C2 - 2191709
SN - 0007-0963
VL - 122
SP - 593
EP - 599
JO - British Journal of Dermatology
JF - British Journal of Dermatology
IS - 5
ER -