TY - JOUR
T1 - Antigen processing in the endocytic compartment
AU - Watts, C.
N1 - Funding Information:
Work in my laboratory is supported by the Wellcome Trust, the European Union and the Association for International Cancer Research.
PY - 2001/2/1
Y1 - 2001/2/1
N2 - Proteolysis generates the peptides that bind to class II MHC molecules and, by destruction of the invariant chain, prepares the class II MHC molecule for capture of those peptides. A clearer picture is emerging of the proteases, protease inhibitors and other factors that together control the environment for class II MHC peptide loading. However, the details of invariant-chain processing and antigen processing may differ depending on the allele of class II and the antigen substrate under consideration.
AB - Proteolysis generates the peptides that bind to class II MHC molecules and, by destruction of the invariant chain, prepares the class II MHC molecule for capture of those peptides. A clearer picture is emerging of the proteases, protease inhibitors and other factors that together control the environment for class II MHC peptide loading. However, the details of invariant-chain processing and antigen processing may differ depending on the allele of class II and the antigen substrate under consideration.
UR - http://www.scopus.com/inward/record.url?scp=0035145332&partnerID=8YFLogxK
U2 - 10.1016/S0952-7915(00)00177-1
DO - 10.1016/S0952-7915(00)00177-1
M3 - Review article
C2 - 11154913
AN - SCOPUS:0035145332
SN - 0952-7915
VL - 13
SP - 26
EP - 31
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 1
ER -