Antigen processing in the endocytic compartment

C. Watts (Lead / Corresponding author)

    Research output: Contribution to journalReview articlepeer-review

    131 Citations (Scopus)


    Proteolysis generates the peptides that bind to class II MHC molecules and, by destruction of the invariant chain, prepares the class II MHC molecule for capture of those peptides. A clearer picture is emerging of the proteases, protease inhibitors and other factors that together control the environment for class II MHC peptide loading. However, the details of invariant-chain processing and antigen processing may differ depending on the allele of class II and the antigen substrate under consideration.

    Original languageEnglish
    Pages (from-to)26-31
    Number of pages6
    JournalCurrent Opinion in Immunology
    Issue number1
    Publication statusPublished - 1 Feb 2001

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology


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