Antioxidant and cytoprotective responses to redox stress

Joanne Mathers, Jennifer A. Fraser, Michael McMahon, Robert D. C. Saunders, John D Hayes, Lesley I. McLellan

    Research output: Contribution to journalArticle

    89 Citations (Scopus)

    Abstract

    Aerobic cells produce reactive oxygen species as a consequence of normal cellular metabolism, and an array of antioxidant systems are in place to maintain the redox balance. When the redox equilibrium of the cell is upset by pro-oxidant environmental stimuli, adaptive responses to the redox stress take place, which can result in up-regulation of antioxidant proteins and detoxification enzymes. Over the past few years, it has become apparent that members of the CNC (cap 'n' collar)-basic leucine zipper family of transcription factors are principal mediators of defensive responses to redox stress. In mammals, the CNC family members nuclear factor-erythroid 2 p45-related factors 1 and 2 (Nrf1 and Nrf2) have been shown to be involved in the transcriptional up-regulation of cytoprotective genes including those encoding glutamate cysteine ligase, NAD(P)H:quinone oxidoreductase, glutathione S-transferases and aldo-keto reductases. An evolutionarily conserved system exists in Caenorhabditis elegans, and it is possible that Drosophila melanogaster may also utilize CNC transcription factors to induce antioxidant genes in response to pro-oxidant chemicals. The advent of microarray and proteomic technologies has advanced our understanding of the gene batteries regulated by oxidative insult, but has highlighted the complexity of gene regulation by environmental factors. This review focuses on the antioxidant response to environmental stress, and the impact that microarrays and proteomics have made in this field.
    Original languageEnglish
    Pages (from-to)157-76
    Number of pages20
    JournalBiochemical Society Symposium
    Issue number71
    Publication statusPublished - 2004

    Fingerprint

    Oxidation-Reduction
    Antioxidants
    Reactive Oxygen Species
    Genes
    Microarrays
    Proteomics
    Transcription Factors
    Up-Regulation
    Basic-Leucine Zipper Transcription Factors
    Glutamate-Cysteine Ligase
    Leucine Zippers
    Detoxification
    Mammals
    Caenorhabditis elegans
    Glutathione Transferase
    Drosophila melanogaster
    Metabolism
    Gene expression
    NAD
    Oxidoreductases

    Cite this

    Mathers, J., Fraser, J. A., McMahon, M., Saunders, R. D. C., Hayes, J. D., & McLellan, L. I. (2004). Antioxidant and cytoprotective responses to redox stress. Biochemical Society Symposium, (71), 157-76.
    Mathers, Joanne ; Fraser, Jennifer A. ; McMahon, Michael ; Saunders, Robert D. C. ; Hayes, John D ; McLellan, Lesley I. / Antioxidant and cytoprotective responses to redox stress. In: Biochemical Society Symposium. 2004 ; No. 71. pp. 157-76.
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    Mathers, J, Fraser, JA, McMahon, M, Saunders, RDC, Hayes, JD & McLellan, LI 2004, 'Antioxidant and cytoprotective responses to redox stress', Biochemical Society Symposium, no. 71, pp. 157-76.

    Antioxidant and cytoprotective responses to redox stress. / Mathers, Joanne; Fraser, Jennifer A.; McMahon, Michael; Saunders, Robert D. C.; Hayes, John D; McLellan, Lesley I.

    In: Biochemical Society Symposium, No. 71, 2004, p. 157-76.

    Research output: Contribution to journalArticle

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    Mathers J, Fraser JA, McMahon M, Saunders RDC, Hayes JD, McLellan LI. Antioxidant and cytoprotective responses to redox stress. Biochemical Society Symposium. 2004;(71):157-76.