Antioxidant synthetic peptides counteracting hyperglycaemia induced endothelial cell dysfunction

TY - JOUR

T1 - Antioxidant synthetic peptides counteracting hyperglycaemia induced endothelial cell dysfunction

AU - Murdoch, Colin E.

AU - De Falco, Elena

N1 - Sapienza University of Rome, Department of Medical Surgical and Biotechnologies; C.E.M. is the coordinator of the Marie Skłodowska-Curie grant No 765274, project iPLACENTA and holds grant No 626633, IVSCP funded by the European Union's Horizon 2020 and Framework 7 research and innovation programme. (This publication reflects only the authors' view and that the European Commission and the Research Executive Agency is not responsible for any use that may be made of the information it contains); C.E.M.'s work is supported by Diabetes UK, grant number 16/0005453, Tenovus Scotland, T18-23.

PY - 2020/6/1

Y1 - 2020/6/1

N2 - In the issue of International Journal of Cardiology, Hemling P. et al. describe that the impairment of thioredoxin (TRX) activity is partially responsible for reactive oxygen species (ROS) accumulation in hyperglycaemic endothelial cells (EC). Interestingly, authors extend this finding to placental arterial EC where the employment of TRX synthetic peptides is able to restore physiological levels of ROS and subsequent improvement of the VEGF-A response, which is diminished in diabetic conditions [1]. The article sheds light on the biological impact of TRX-based as a link between the redox systems and endothelial function in hyperglycaemia.

AB - In the issue of International Journal of Cardiology, Hemling P. et al. describe that the impairment of thioredoxin (TRX) activity is partially responsible for reactive oxygen species (ROS) accumulation in hyperglycaemic endothelial cells (EC). Interestingly, authors extend this finding to placental arterial EC where the employment of TRX synthetic peptides is able to restore physiological levels of ROS and subsequent improvement of the VEGF-A response, which is diminished in diabetic conditions [1]. The article sheds light on the biological impact of TRX-based as a link between the redox systems and endothelial function in hyperglycaemia.

UR - https://www.scopus.com/pages/publications/85082824586

U2 - 10.1016/j.ijcard.2020.03.051

DO - 10.1016/j.ijcard.2020.03.051

M3 - Editorial

C2 - 32247574

SN - 0167-5273

VL - 308

SP - 82

EP - 83

JO - International Journal of Cardiology

JF - International Journal of Cardiology

ER -