Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines

Burkhard Klenke, Michael P. Barrett, Reto Brun, Ian H. Gilbert

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    26 Citations (Scopus)

    Abstract

    Polyamine biosynthesis and function has been shown to be a good drug target in some parasitic protozoa and it is proposed that the pathway might also represent a target in the malaria parasite Plasmodium falciparum. A series of 1,3,5-triazine-substituted polyamine analogues were tested for activity against Plasmodium falciparum in vitro. The series showed activity against the parasites and were generally more active against the chloroquine-resistant line K1 than the chloroquine-susceptible line NF54. Simple unbranched analogues had better activity than analogues carrying branched or cyclic central chains. Addition of multiple triazine units in general led to increased activity of the compounds.

    Original languageEnglish
    Pages (from-to)290-293
    Number of pages4
    JournalJournal of Antimicrobial Chemotherapy
    Volume52
    Issue number2
    DOIs
    Publication statusPublished - Aug 2003

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