TY - JOUR
T1 - Antiplasmodial and anti-trypanosomial monoterpene indole alkaloids from Picralima nitida
AU - Laryea, Michael Konney
AU - Abotsi, Kofi Mensah Wonder
AU - Woode, Eric
AU - Dickson, Rita Akosua
AU - Webster, Lauren
AU - Ekuadzi, Edmund
N1 - Publisher Copyright:
© 2024 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2024/11/28
Y1 - 2024/11/28
N2 - Eight monoterpene indole alkaloids (1–8), including one new picraline-type alkaloid, 2-hydroxyakuammiline (4) and seven known compounds: akuammigine (1), akuammine (2), akuammidine (3), akuammiline (5a), akuammiline N-oxide (5b), akuammiline (6), rhazimol (7), and alstonine (8) were isolated from the seeds of Picralima nitida. Structure elucidation was done by analysis of their MS and NMR spectroscopic data. The antiplasmodial effects of compounds 1–7 were moderate. Compound 8 showed significant effects with pXC50 of 6.3. Compounds 1 and 7 showed significant trypanocidal effects with pXC50’s of 5.1 and 5.4 respectively.
AB - Eight monoterpene indole alkaloids (1–8), including one new picraline-type alkaloid, 2-hydroxyakuammiline (4) and seven known compounds: akuammigine (1), akuammine (2), akuammidine (3), akuammiline (5a), akuammiline N-oxide (5b), akuammiline (6), rhazimol (7), and alstonine (8) were isolated from the seeds of Picralima nitida. Structure elucidation was done by analysis of their MS and NMR spectroscopic data. The antiplasmodial effects of compounds 1–7 were moderate. Compound 8 showed significant effects with pXC50 of 6.3. Compounds 1 and 7 showed significant trypanocidal effects with pXC50’s of 5.1 and 5.4 respectively.
KW - 2-hydroxyakuammiline
KW - akuamma
KW - Chagas disease
KW - malaria
KW - Plasmodium falciparum
KW - Trypanosoma cruzi
UR - http://www.scopus.com/inward/record.url?scp=85210554370&partnerID=8YFLogxK
U2 - 10.1080/14786419.2024.2434710
DO - 10.1080/14786419.2024.2434710
M3 - Article
C2 - 39605297
AN - SCOPUS:85210554370
SN - 1478-6419
JO - Natural Product Research
JF - Natural Product Research
ER -
