Aortic valvular heart disease: is there a place for angiotensin-converting-enzyme inhibitors?

Douglas H J Elder, Victoria McAlpine-Scott, Anna Maria Choy, Allan D Struthers, Chim C Lang

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    Aortic valve disease (AVD) is the most common form of valvular heart disease in the western world. The only proven therapy for severe AVD is open aortic valve replacement, with trans-catheter aortic valve implantation emerging as a promising modality to treat severe aortic stenosis in a selected group of patients. AVD has a long asymptomatic phase with symptoms occurring late in the disease and once symptoms develop, prognosis is poor. There is a growing appreciation that aortic valvular heart disease incorporates a disease process that extends beyond the valve itself leading to an aortic valvular 'heart' disease. The renin-angiotensin system is known to modulate adverse left ventricular remodeling and myocardial fibrosis, which could be caused by increased load caused by the AVD. In this review, the authors explore evidence that suggest that drugs that target the renin-angiotensin system may have a potential therapeutic role in AVD.
    Original languageEnglish
    Pages (from-to)107-14
    Number of pages8
    JournalExpert Review of Cardiovascular Therapy
    Volume11
    Issue number1
    DOIs
    Publication statusPublished - Jan 2013

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