As Thailand is entering an aging society, one of the important chronic diseases of Thai elderly population is dementia including Alzheimer's disease (AD). AD is a heritable and the most common type of senile dementia. In addition to the major genetic determinant of AD, the Apolipoprotein E (ApoE) genetic variants have been associated. The human ApoE gene is derived from the polymorphic combination of ApoE rs429358 and rs7412 that results in ApoE-ε2, ApoE-ε3 and ApoE-ε4 isoforms. The associations between ApoE genetic variants and the risk of AD have been demonstrated in numerous epidemiological studies in Caucasians but very less established in Asians, especially in Southern Thai population. We hereby assessed the distributions of these ApoE variants on aging population with cognitive impairment/dementia diagnosed in Nakhon Si Thammarat as a preliminary study for further study on the effects of these variants in all cause dementia among population.
|Conference||International Conference on the 4th Industrial Revolution and its Impacts Program of Presentations|
|City||Nakhon Si Thammarat|
|Period||27/03/19 → 30/03/19|
- Apolipoprotein E