Apolipoprotein E Gene Polymorphism in Aging Population with Dementia in Nakhon Si Thammarat: A Preliminary Study of Southern Thai Ethnicity

Tharin Phenwan (Contributing member), Apsorn Sattayakhom (Lead / Corresponding author), Sarawoot Palipoch (Contributing member), Chuchard Punsawad (Contributing member), Prasit Na-Ek (Contributing member), Wasinee Poonsawat (Research group member), Nattawan Kumanee (Research group member), Phanit Koomhin

Research output: Contribution to conferencePoster

Abstract

As Thailand is entering an aging society, one of the important chronic diseases of Thai elderly population is dementia including Alzheimer's disease (AD). AD is a heritable and the most common type of senile dementia. In addition to the major genetic determinant of AD, the Apolipoprotein E (ApoE) genetic variants have been associated. The human ApoE gene is derived from the polymorphic combination of ApoE rs429358 and rs7412 that results in ApoE-ε2, ApoE-ε3 and ApoE-ε4 isoforms. The associations between ApoE genetic variants and the risk of AD have been demonstrated in numerous epidemiological studies in Caucasians but very less established in Asians, especially in Southern Thai population. We hereby assessed the distributions of these ApoE variants on aging population with cognitive impairment/dementia diagnosed in Nakhon Si Thammarat as a preliminary study for further study on the effects of these variants in all cause dementia among population.
Original languageEnglish
Publication statusPublished - 27 Mar 2019
EventInternational Conference on the 4th Industrial Revolution and its Impacts Program of Presentations - Walailak University, Nakhon Si Thammarat, Thailand
Duration: 27 Mar 201930 Mar 2019
https://ic4ir.wu.ac.th/

Conference

ConferenceInternational Conference on the 4th Industrial Revolution and its Impacts Program of Presentations
Abbreviated titleIC4ir2019
CountryThailand
CityNakhon Si Thammarat
Period27/03/1930/03/19
Internet address

Keywords

  • Dementia
  • Thailand
  • Apolipoprotein E
  • Polymorphism

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    Phenwan, T., Sattayakhom, A., Palipoch, S., Punsawad, C., Na-Ek, P., Poonsawat, W., Kumanee, N., & Koomhin, P. (2019). Apolipoprotein E Gene Polymorphism in Aging Population with Dementia in Nakhon Si Thammarat: A Preliminary Study of Southern Thai Ethnicity. Poster session presented at International Conference on the 4th Industrial Revolution and its Impacts Program of Presentations, Nakhon Si Thammarat, Thailand.