Apolipoprotein E Gene Polymorphism in Aging Population with Dementia in Nakhon Si Thammarat: A Preliminary Study of Southern Thai Ethnicity

Tharin Phenwan; Apsorn Sattayakhom; Sarawoot Palipoch; Chuchard Punsawad; Prasit Na-Ek; Wasinee Poonsawat; Nattawan Kumanee; Phanit Koomhin

Apolipoprotein E Gene Polymorphism in Aging Population with Dementia in Nakhon Si Thammarat: A Preliminary Study of Southern Thai Ethnicity

Tharin Phenwan (Contributing member), Apsorn Sattayakhom (Lead / Corresponding author), Sarawoot Palipoch (Contributing member), Chuchard Punsawad (Contributing member), Prasit Na-Ek (Contributing member), Wasinee Poonsawat (Research group member), Nattawan Kumanee (Research group member), Phanit Koomhin

Health Sciences

Research output: Contribution to conference › Poster › peer-review

Abstract

As Thailand is entering an aging society, one of the important chronic diseases of Thai elderly population is dementia including Alzheimer's disease (AD). AD is a heritable and the most common type of senile dementia. In addition to the major genetic determinant of AD, the Apolipoprotein E (ApoE) genetic variants have been associated. The human ApoE gene is derived from the polymorphic combination of ApoE rs429358 and rs7412 that results in ApoE-ε2, ApoE-ε3 and ApoE-ε4 isoforms. The associations between ApoE genetic variants and the risk of AD have been demonstrated in numerous epidemiological studies in Caucasians but very less established in Asians, especially in Southern Thai population. We hereby assessed the distributions of these ApoE variants on aging population with cognitive impairment/dementia diagnosed in Nakhon Si Thammarat as a preliminary study for further study on the effects of these variants in all cause dementia among population.

Original language	English
Publication status	Published - 27 Mar 2019
Event	International Conference on the 4th Industrial Revolution and its Impacts Program of Presentations - Walailak University, Nakhon Si Thammarat, Thailand Duration: 27 Mar 2019 → 30 Mar 2019 https://ic4ir.wu.ac.th/

Conference

Conference	International Conference on the 4th Industrial Revolution and its Impacts Program of Presentations
Abbreviated title	IC4ir2019
Country/Territory	Thailand
City	Nakhon Si Thammarat
Period	27/03/19 → 30/03/19
Internet address	https://ic4ir.wu.ac.th/

Keywords

Dementia
Thailand
Apolipoprotein E
Polymorphism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

Phenwan, T., Sattayakhom, A., Palipoch, S., Punsawad, C., Na-Ek, P., Poonsawat, W., Kumanee, N., & Koomhin, P. (2019). Apolipoprotein E Gene Polymorphism in Aging Population with Dementia in Nakhon Si Thammarat: A Preliminary Study of Southern Thai Ethnicity. Poster session presented at International Conference on the 4th Industrial Revolution and its Impacts Program of Presentations, Nakhon Si Thammarat, Thailand.

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title = "Apolipoprotein E Gene Polymorphism in Aging Population with Dementia in Nakhon Si Thammarat: A Preliminary Study of Southern Thai Ethnicity",

abstract = "As Thailand is entering an aging society, one of the important chronic diseases of Thai elderly population is dementia including Alzheimer's disease (AD). AD is a heritable and the most common type of senile dementia. In addition to the major genetic determinant of AD, the Apolipoprotein E (ApoE) genetic variants have been associated. The human ApoE gene is derived from the polymorphic combination of ApoE rs429358 and rs7412 that results in ApoE-ε2, ApoE-ε3 and ApoE-ε4 isoforms. The associations between ApoE genetic variants and the risk of AD have been demonstrated in numerous epidemiological studies in Caucasians but very less established in Asians, especially in Southern Thai population. We hereby assessed the distributions of these ApoE variants on aging population with cognitive impairment/dementia diagnosed in Nakhon Si Thammarat as a preliminary study for further study on the effects of these variants in all cause dementia among population.",

keywords = "Dementia, Thailand, Apolipoprotein E, Polymorphism",

author = "Tharin Phenwan and Apsorn Sattayakhom and Sarawoot Palipoch and Chuchard Punsawad and Prasit Na-Ek and Wasinee Poonsawat and Nattawan Kumanee and Phanit Koomhin",

year = "2019",

month = mar,

day = "27",

language = "English",

note = "International Conference on the 4th Industrial Revolution and its Impacts Program of Presentations, IC4ir2019 ; Conference date: 27-03-2019 Through 30-03-2019",

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Phenwan, T, Sattayakhom, A, Palipoch, S, Punsawad, C, Na-Ek, P, Poonsawat, W, Kumanee, N & Koomhin, P 2019, 'Apolipoprotein E Gene Polymorphism in Aging Population with Dementia in Nakhon Si Thammarat: A Preliminary Study of Southern Thai Ethnicity', International Conference on the 4th Industrial Revolution and its Impacts Program of Presentations, Nakhon Si Thammarat, Thailand, 27/03/19 - 30/03/19.

Apolipoprotein E Gene Polymorphism in Aging Population with Dementia in Nakhon Si Thammarat: A Preliminary Study of Southern Thai Ethnicity. / Phenwan, Tharin (Contributing member); Sattayakhom, Apsorn (Lead / Corresponding author); Palipoch, Sarawoot (Contributing member) et al.
2019. Poster session presented at International Conference on the 4th Industrial Revolution and its Impacts Program of Presentations, Nakhon Si Thammarat, Thailand.

Research output: Contribution to conference › Poster › peer-review

TY - CONF

T1 - Apolipoprotein E Gene Polymorphism in Aging Population with Dementia in Nakhon Si Thammarat: A Preliminary Study of Southern Thai Ethnicity

AU - Sattayakhom, Apsorn

AU - Koomhin, Phanit

A2 - Phenwan, Tharin

A2 - Palipoch, Sarawoot

A2 - Punsawad, Chuchard

A2 - Na-Ek, Prasit

A2 - Poonsawat, Wasinee

A2 - Kumanee, Nattawan

PY - 2019/3/27

Y1 - 2019/3/27

N2 - As Thailand is entering an aging society, one of the important chronic diseases of Thai elderly population is dementia including Alzheimer's disease (AD). AD is a heritable and the most common type of senile dementia. In addition to the major genetic determinant of AD, the Apolipoprotein E (ApoE) genetic variants have been associated. The human ApoE gene is derived from the polymorphic combination of ApoE rs429358 and rs7412 that results in ApoE-ε2, ApoE-ε3 and ApoE-ε4 isoforms. The associations between ApoE genetic variants and the risk of AD have been demonstrated in numerous epidemiological studies in Caucasians but very less established in Asians, especially in Southern Thai population. We hereby assessed the distributions of these ApoE variants on aging population with cognitive impairment/dementia diagnosed in Nakhon Si Thammarat as a preliminary study for further study on the effects of these variants in all cause dementia among population.

AB - As Thailand is entering an aging society, one of the important chronic diseases of Thai elderly population is dementia including Alzheimer's disease (AD). AD is a heritable and the most common type of senile dementia. In addition to the major genetic determinant of AD, the Apolipoprotein E (ApoE) genetic variants have been associated. The human ApoE gene is derived from the polymorphic combination of ApoE rs429358 and rs7412 that results in ApoE-ε2, ApoE-ε3 and ApoE-ε4 isoforms. The associations between ApoE genetic variants and the risk of AD have been demonstrated in numerous epidemiological studies in Caucasians but very less established in Asians, especially in Southern Thai population. We hereby assessed the distributions of these ApoE variants on aging population with cognitive impairment/dementia diagnosed in Nakhon Si Thammarat as a preliminary study for further study on the effects of these variants in all cause dementia among population.

KW - Dementia

KW - Thailand

KW - Apolipoprotein E

KW - Polymorphism

UR - https://ic4ir.wu.ac.th/

M3 - Poster

T2 - International Conference on the 4th Industrial Revolution and its Impacts Program of Presentations

Y2 - 27 March 2019 through 30 March 2019

ER -

Phenwan T, Sattayakhom A, Palipoch S, Punsawad C, Na-Ek P, Poonsawat W et al.. Apolipoprotein E Gene Polymorphism in Aging Population with Dementia in Nakhon Si Thammarat: A Preliminary Study of Southern Thai Ethnicity. 2019. Poster session presented at International Conference on the 4th Industrial Revolution and its Impacts Program of Presentations, Nakhon Si Thammarat, Thailand.

Apolipoprotein E Gene Polymorphism in Aging Population with Dementia in Nakhon Si Thammarat: A Preliminary Study of Southern Thai Ethnicity

Abstract

Conference

Keywords

UN SDGs

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Dementia Community Screening Program in District Health Area 11: Phase 1

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