Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121

TY - JOUR

T1 - Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121

AU - Hudson, Sean A.

AU - McLean, Kirsty J.

AU - Surade, S.

AU - Yang, Yong-Qing

AU - Leys, David

AU - Ciulli, Alessio

AU - Munro, Andrew W.

AU - Abell, C.

N1 - MEDLINE® is the source for the MeSH terms of this document.

PY - 2012/9/10

Y1 - 2012/9/10

N2 - Pieces of the puzzle: The first fragment-based approach was used to target cytochrome P450 enzymes (CYPs) for drug development (see scheme). The experiments provide new insights into the binding site of the essential Mycobacterium tuberculosis CYP121 enzyme, and resulted in a promising novel lead compound based on fragment merging.

AB - Pieces of the puzzle: The first fragment-based approach was used to target cytochrome P450 enzymes (CYPs) for drug development (see scheme). The experiments provide new insights into the binding site of the essential Mycobacterium tuberculosis CYP121 enzyme, and resulted in a promising novel lead compound based on fragment merging.

UR - https://www.scopus.com/pages/publications/84865835782

U2 - 10.1002/anie.201202544

DO - 10.1002/anie.201202544

M3 - Article

C2 - 22890978

AN - SCOPUS:84865835782

SN - 1433-7851

VL - 51

SP - 9311

EP - 9316

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 37

ER -