Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121

Keyphrases

• Mycobacterium Tuberculosis (M. tb) 100%
• Cytochrome P450 (CYP450) 100%
• Fragment Screening 100%
• CYP121 100%
• Fragment Merging 100%
• Drug Development 50%
• Binding Site 50%
• Cytochrome P450 Enzymes 50%
• Novel Leads 50%
• Fragment-based Approach 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Cytochrome P450 100%
• Mycobacterium Tuberculosis 100%
• Binding Site 50%
• Drug Development 50%
• Lead Compound 50%

Chemistry

• Cytochrome P450 100%
• Binding Site 50%
• Lead Compound 50%