Application of higher-order spectra for the characterization of Coronary artery disease using electrocardiogram signals

U. Rajendra Acharya, Vidya K. Sudarshan, Joel E.w. Koh, Roshan Joy Martis, Jen Hong Tan, Shu Lih Oh, Adam Muhammad, Yuki Hagiwara, Muthu Rama Krishanan Mookiah, Kok Poo Chua, Chua K Chua, Ru San Tan

Research output: Contribution to journalArticlepeer-review

108 Citations (Scopus)


Coronary Artery Disease (CAD) is the root cause for chain of catastrophic heart diseases such as Ischemic Heart Disease (IHD), Myocardial Infarction (MI) or Heart Attack (HA) and Heart Failure (HF). Early detection and treatment of this CAD condition is essential and may help in preventing it from progressing further. However, faster and accurate identification of CAD from Electrocardiogram (ECG) signals using manual interpretations is not an easy task to achieve. Thus, computer-aided techniques are necessary for the automated characterization of CAD condition. Therefore, this work proposes application of Higher-Order Statistics and Spectra (HOS) for an automated classification of normal and CAD conditions using ECG signals. In this paper, 182,013 beats (137,587 normal beats and 44,426 beats with CAD) ECG beats are used. HOS bispectrum and cumulant features are extracted from each ECG beat. The features extracted are applied to Principal Component Analysis (PCA) dimension reduction technique. Then PCA coefficients are ranked using Bhattacharyya method, entropy, fuzzy Max-Relevancy and Min-Redundancy (mRMR), Receiver Operating Characteristics (ROC), t-test, Wilcoxon ranking methods. All ranked features are subjected to k-Nearest Neighbors (KNN) and Decision Tree (DT) classifiers to obtain the highest classification performance. The proposed methodology has achieved 98.17% accuracy, 94.57% sensitivity, and 99.34% specificity, using KNN classifier using 13 bispectrum features. Similarly, we have obtained 98.99% average accuracy, 97.75% sensitivity, and 99.39% specificity using DT classifier with 31 cumulant features. In addition, we have formulated and developed an integrated index called Coronary Artery Disease Index (CADI) for automated characterization of normal and ECG signals with CAD condition using a single number. This proposed CADI works efficiently to discriminate normal and CAD ECG classes for the any dataset with priory knowledge of the database.

Original languageEnglish
Pages (from-to)31-43
JournalBiomedical Signal Processing and Control
Early online date19 Jul 2016
Publication statusPublished - Jan 2017


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