Application of Humanised and Other Transgenic Models to Predict Human Responses to Drugs

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The use of transgenic animal models has transformed our knowledge of complex biochemical pathways in vivo. It has allowed disease processes to be modelled and used in the development of new disease prevention and treatment strategies. They can also be used to define cell- and tissue-specific pathways of gene regulation. A further major application is in the area of preclinical development where such models can be used to define pathways of chemical toxicity, and the pathways that regulate drug disposition. One major application of this approach is the humanisation of mice for the proteins that control drug metabolism and disposition. Such models can have numerous applications in the development of drugs and in their more sophisticated use in the clinic.

Original languageEnglish
Title of host publicationNew Horizons in Predictive drug Metabolism and Pharmocokentics
PublisherRoyal Society of Chemistry
Pages152-176
Number of pages25
Volume2016-January
Edition49
ISBN (Electronic)9781782622376
ISBN (Print)9781849738286
DOIs
Publication statusPublished - 20 Nov 2016

Publication series

NameRSC Drug Discovery Series
Number49
Volume2016-January
ISSN (Print)20413203
ISSN (Electronic)20413211

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    Wolf, C. R., Kapelyukh, Y., Scheer, N., & Henderson, C. J. (2016). Application of Humanised and Other Transgenic Models to Predict Human Responses to Drugs. In New Horizons in Predictive drug Metabolism and Pharmocokentics (49 ed., Vol. 2016-January, pp. 152-176). (RSC Drug Discovery Series; Vol. 2016-January, No. 49). Royal Society of Chemistry. https://doi.org/10.1039/9781782622376-00152