Application of optical trapping for cavitation studies

P. A. Prentice; P. A. Campbell

doi:10.1117/12.794192

Application of optical trapping for cavitation studies

P. A. Prentice, P. A. Campbell

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

This study has observed microscopic level cavitation processes in shelled second generation ultrasound contrast agent microbubbles. The spatial and temporal resolutions required for this undertaking have been achieved via a unique hybridisation of optical trapping with ultra high speed microphotography. Upon insonation with ultrasound in the region of 0.5-4MPa, microjets were observed to develop within, and subsequently issue from, cavitating bubbles. Jet impact into target substrates, including monolayers of biological cells, was observed. These observations provide direct evidence for the involvement of microjetting events during ultrasound exposure on live cells, a process that may have future potential as a novel non-invasive route to drug- and gene-based therapies.

Original language	English
Title of host publication	Optical Trapping and Optical Micromanipulation V
Editors	Kishan Dholakia, Gabriel C. Spalding
Place of Publication	Bellingham
Publisher	SPIE-International Society for Optical Engineering
Number of pages	8
ISBN (Print)	9780819472588
DOIs	https://doi.org/10.1117/12.794192
Publication status	Published - 2008
Event	SPIE Optics+Photonics 2008: Optical Trapping and Optical Micromanipulation V - San Diego Convention Center, San Diego, United States Duration: 10 Aug 2008 → 13 Aug 2008 http://spie.org/x27421.xml

Publication series

Name	Proceedings of SPIE
Publisher	SPIE
Volume	7038

Conference

Conference	SPIE Optics+Photonics 2008: Optical Trapping and Optical Micromanipulation V
Abbreviated title	http://spie.org/x27421.xml
Country/Territory	United States
City	San Diego
Period	10/08/08 → 13/08/08
Internet address	http://spie.org/x27421.xml

Keywords

Optical trapping
microbubbles
acoustic cavitation
ultrasound
drug delivery
CONTRAST AGENTS
BUBBLE COLLAPSE
GENE-TRANSFER
CELL-LYSIS
IN-VIVO
ULTRASOUND
LASER
TRANSFECTION
BOUNDARIES
PRESSURES

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10.1117/12.794192

Cite this

@inproceedings{b086f68a8f3943c3881422d93d5571d8,

title = "Application of optical trapping for cavitation studies",

abstract = "This study has observed microscopic level cavitation processes in shelled second generation ultrasound contrast agent microbubbles. The spatial and temporal resolutions required for this undertaking have been achieved via a unique hybridisation of optical trapping with ultra high speed microphotography. Upon insonation with ultrasound in the region of 0.5-4MPa, microjets were observed to develop within, and subsequently issue from, cavitating bubbles. Jet impact into target substrates, including monolayers of biological cells, was observed. These observations provide direct evidence for the involvement of microjetting events during ultrasound exposure on live cells, a process that may have future potential as a novel non-invasive route to drug- and gene-based therapies.",

keywords = "Optical trapping, microbubbles, acoustic cavitation, ultrasound, drug delivery, CONTRAST AGENTS, BUBBLE COLLAPSE, GENE-TRANSFER, CELL-LYSIS, IN-VIVO, ULTRASOUND, LASER, TRANSFECTION, BOUNDARIES, PRESSURES",

author = "Prentice, {P. A.} and Campbell, {P. A.}",

year = "2008",

doi = "10.1117/12.794192",

language = "English",

isbn = "9780819472588",

series = "Proceedings of SPIE",

publisher = "SPIE-International Society for Optical Engineering",

editor = "Kishan Dholakia and Spalding, {Gabriel C.}",

booktitle = "Optical Trapping and Optical Micromanipulation V",

note = "SPIE Optics+Photonics 2008: Optical Trapping and Optical Micromanipulation V, http://spie.org/x27421.xml ; Conference date: 10-08-2008 Through 13-08-2008",

url = "http://spie.org/x27421.xml",

}

Prentice, PA & Campbell, PA 2008, Application of optical trapping for cavitation studies. in K Dholakia & GC Spalding (eds), Optical Trapping and Optical Micromanipulation V., 70381N , Proceedings of SPIE, vol. 7038, SPIE-International Society for Optical Engineering, Bellingham, SPIE Optics+Photonics 2008: Optical Trapping and Optical Micromanipulation V, San Diego, United States, 10/08/08. https://doi.org/10.1117/12.794192

Application of optical trapping for cavitation studies. / Prentice, P. A.; Campbell, P. A.
Optical Trapping and Optical Micromanipulation V. ed. / Kishan Dholakia; Gabriel C. Spalding. Bellingham: SPIE-International Society for Optical Engineering, 2008. 70381N (Proceedings of SPIE; Vol. 7038).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Application of optical trapping for cavitation studies

AU - Prentice, P. A.

AU - Campbell, P. A.

PY - 2008

Y1 - 2008

N2 - This study has observed microscopic level cavitation processes in shelled second generation ultrasound contrast agent microbubbles. The spatial and temporal resolutions required for this undertaking have been achieved via a unique hybridisation of optical trapping with ultra high speed microphotography. Upon insonation with ultrasound in the region of 0.5-4MPa, microjets were observed to develop within, and subsequently issue from, cavitating bubbles. Jet impact into target substrates, including monolayers of biological cells, was observed. These observations provide direct evidence for the involvement of microjetting events during ultrasound exposure on live cells, a process that may have future potential as a novel non-invasive route to drug- and gene-based therapies.

AB - This study has observed microscopic level cavitation processes in shelled second generation ultrasound contrast agent microbubbles. The spatial and temporal resolutions required for this undertaking have been achieved via a unique hybridisation of optical trapping with ultra high speed microphotography. Upon insonation with ultrasound in the region of 0.5-4MPa, microjets were observed to develop within, and subsequently issue from, cavitating bubbles. Jet impact into target substrates, including monolayers of biological cells, was observed. These observations provide direct evidence for the involvement of microjetting events during ultrasound exposure on live cells, a process that may have future potential as a novel non-invasive route to drug- and gene-based therapies.

KW - Optical trapping

KW - microbubbles

KW - acoustic cavitation

KW - ultrasound

KW - drug delivery

KW - CONTRAST AGENTS

KW - BUBBLE COLLAPSE

KW - GENE-TRANSFER

KW - CELL-LYSIS

KW - IN-VIVO

KW - ULTRASOUND

KW - LASER

KW - TRANSFECTION

KW - BOUNDARIES

KW - PRESSURES

U2 - 10.1117/12.794192

DO - 10.1117/12.794192

M3 - Conference contribution

SN - 9780819472588

T3 - Proceedings of SPIE

BT - Optical Trapping and Optical Micromanipulation V

A2 - Dholakia, Kishan

A2 - Spalding, Gabriel C.

PB - SPIE-International Society for Optical Engineering

CY - Bellingham

T2 - SPIE Optics+Photonics 2008: Optical Trapping and Optical Micromanipulation V

Y2 - 10 August 2008 through 13 August 2008

ER -

Application of optical trapping for cavitation studies

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