Application of optical trapping for cavitation studies

P. A. Prentice, P. A. Campbell

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)

    Abstract

    This study has observed microscopic level cavitation processes in shelled second generation ultrasound contrast agent microbubbles. The spatial and temporal resolutions required for this undertaking have been achieved via a unique hybridisation of optical trapping with ultra high speed microphotography. Upon insonation with ultrasound in the region of 0.5-4MPa, microjets were observed to develop within, and subsequently issue from, cavitating bubbles. Jet impact into target substrates, including monolayers of biological cells, was observed. These observations provide direct evidence for the involvement of microjetting events during ultrasound exposure on live cells, a process that may have future potential as a novel non-invasive route to drug- and gene-based therapies.

    Original languageEnglish
    Title of host publicationOptical Trapping and Optical Micromanipulation V
    EditorsKishan Dholakia, Gabriel C. Spalding
    Place of PublicationBellingham
    PublisherSPIE-International Society for Optical Engineering
    Number of pages8
    ISBN (Print)9780819472588
    DOIs
    Publication statusPublished - 2008
    EventSPIE Optics+Photonics 2008: Optical Trapping and Optical Micromanipulation V - San Diego Convention Center, San Diego, United States
    Duration: 10 Aug 200813 Aug 2008
    http://spie.org/x27421.xml

    Publication series

    NameProceedings of SPIE
    PublisherSPIE
    Volume7038

    Conference

    ConferenceSPIE Optics+Photonics 2008: Optical Trapping and Optical Micromanipulation V
    Abbreviated titlehttp://spie.org/x27421.xml
    CountryUnited States
    CitySan Diego
    Period10/08/0813/08/08
    Internet address

    Keywords

    • Optical trapping
    • microbubbles
    • acoustic cavitation
    • ultrasound
    • drug delivery
    • CONTRAST AGENTS
    • BUBBLE COLLAPSE
    • GENE-TRANSFER
    • CELL-LYSIS
    • IN-VIVO
    • ULTRASOUND
    • LASER
    • TRANSFECTION
    • BOUNDARIES
    • PRESSURES

    Cite this

    Prentice, P. A., & Campbell, P. A. (2008). Application of optical trapping for cavitation studies. In K. Dholakia, & G. C. Spalding (Eds.), Optical Trapping and Optical Micromanipulation V [70381N ] (Proceedings of SPIE; Vol. 7038). SPIE-International Society for Optical Engineering. https://doi.org/10.1117/12.794192