Approaching Neutrophil Pyroptosis

Gabriel Sollberger (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

All cells must die at some point, and the dogma is that they do it either silently via apoptosis or via pro-inflammatory, lytic forms of death. Amongst these lytic cell death pathways, pyroptosis is one of the best characterized. Pyroptosis depends on inflammatory caspases which activate members of the gasdermin family of proteins, and it is associated with the release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18. Pyroptosis is an essential component of innate immunity, it initiates and amplifies inflammation and it removes the replication niche for intracellular pathogens. Most of the literature on pyroptosis focuses on monocytes and macrophages. However, the most abundant phagocytes in humans are neutrophils. This review addresses whether neutrophils undergo pyroptosis and the underlying mechanisms. Furthermore, I discuss how and why neutrophils might be able to resist pyroptosis.

Original languageEnglish
Article number167335
Number of pages16
JournalJournal of Molecular Biology
Volume434
Issue number4
Early online date29 Oct 2021
DOIs
Publication statusPublished - 28 Feb 2022

Keywords

  • cell death
  • inflammation
  • NET formation
  • neutrophil
  • pyroptosis

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