Are Current Cancer Treatments on Target for Our Ageing Cancer Population?

TY - JOUR

T1 - Are Current Cancer Treatments on Target for Our Ageing Cancer Population?

AU - Baxter, Mark

AU - Cheung, Kwok-Leung

AU - Battisti, Nicolò Matteo Luca

PY - 2023/6/30

Y1 - 2023/6/30

N2 - Worldwide the cancer population is ageing – within a decade almost two-thirds of newly diagnosed patients will be aged 65 years and older. Despite this, the majority of oncology clinical trials continue to recruit patients who are younger and fitter than those typically encountered in clinical practice. As such, there is a lack of clinical data to guide management, particularly in those patients living with frailty and/or comorbidity. Importantly, the lack of older adults in trials also means that the subsequent translational work that underpins biomarker and therapeutic discovery may not be relevant to those we see in clinic. In this commentary, we discuss this challenge and the ways we as an Oncology community can look to address this pressing issue.

AB - Worldwide the cancer population is ageing – within a decade almost two-thirds of newly diagnosed patients will be aged 65 years and older. Despite this, the majority of oncology clinical trials continue to recruit patients who are younger and fitter than those typically encountered in clinical practice. As such, there is a lack of clinical data to guide management, particularly in those patients living with frailty and/or comorbidity. Importantly, the lack of older adults in trials also means that the subsequent translational work that underpins biomarker and therapeutic discovery may not be relevant to those we see in clinic. In this commentary, we discuss this challenge and the ways we as an Oncology community can look to address this pressing issue.

UR - https://ojs.gs-publishing.uk/index.php/ACRT/article/view/63

U2 - 10.37155/2972-4759-2023-01-01-5

DO - 10.37155/2972-4759-2023-01-01-5

M3 - Comment/debate

SN - 2972-4767

VL - 1

JO - Ageing and Cancer Research & Treatment

JF - Ageing and Cancer Research & Treatment

IS - 1

M1 - 63

ER -