Are we closer to seeing carcinoma in situ in the upper urinary tract?

Sławomir G. Kata (Lead / Corresponding author), Omar Aboumarzouk

    Research output: Contribution to journalReview article

    Abstract

    INTRODUCTION: There is observed increase in detection rate of upper urinary tract urothelial cancer worldwide. This is a result of improved imaging as well as implementation of novel technologies of direct visualization of upper urinary tract. Standard techniques still remain insufficient to diagnose flat urothelial lesions. Carcinoma in situ is characterized by flat disordered proliferation of urothelial cells with marked cytologic abnormality, which occur within one cell layer as well as full thickness urothelium and therefore requires a better technology to pick up early and subtle mucosal changes.

    MATERIAL AND METHODS: The review presents available diagnostic tools in detection of upper urinary tract urothelial cancer and their ability to depict carcinoma in situ.

    RESULTS: Ureterorenoscopy is an investigation of choice as various promising techniques are under pilot investigations to enhance visualization of upper urinary tract carcinoma in situ. So far only photodynamic diagnosis has been reported to be as effective in detection of carcinoma in situ in the upper as within the lower urinary tract.

    CONCLUSIONS: Although we are close to see upper urinary tract carcinoma in situ all new promising diagnostic techniques still require further validation in multicenter clinical trials to indicate any change to current recommendations.

    Original languageEnglish
    Pages (from-to)157-161
    Number of pages5
    JournalCentral European Journal of Urology
    Volume69
    Issue number2
    Early online date26 Apr 2016
    DOIs
    Publication statusPublished - 2016

    Keywords

    • upper urinary tract
    • urothelial cancer
    • carcinoma in situ
    • detection

    Fingerprint Dive into the research topics of 'Are we closer to seeing carcinoma in situ in the upper urinary tract?'. Together they form a unique fingerprint.

  • Cite this