Argonaute proteins: key players in RNA silencing

Gyorgy Hutvagner, Martin J Simard

    Research output: Contribution to journalArticlepeer-review

    1003 Citations (Scopus)


    During the past decade, small non-coding RNAs have rapidly emerged as important contributors to gene regulation. To carry out their biological functions, these small RNAs require a unique class of proteins called Argonautes. The discovery and our comprehension of this highly conserved protein family is closely linked to the study of RNA-based gene silencing mechanisms. With their functional domains, Argonaute proteins can bind small non-coding RNAs and control protein synthesis, affect messenger RNA stability and even participate in the production of a new class of small RNAs, Piwi-interacting RNAs.
    Original languageEnglish
    Pages (from-to)22-32
    Number of pages11
    JournalNature Reviews Molecular Cell Biology
    Issue number1
    Publication statusPublished - Jan 2008


    • Animals
    • Arabidopsis Proteins
    • Argonaute Proteins
    • Drosophila Proteins
    • Eukaryotic Initiation Factor-2
    • Eukaryotic Initiation Factors
    • Evolution, Molecular
    • Germ Cells
    • Humans
    • Plants
    • Protein Structure, Tertiary
    • RNA Interference
    • RNA Stability
    • RNA, Small Interfering
    • RNA, Untranslated


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