Array-based sequencing of filaggrin gene for comprehensive detection of disease-associated variants

X. F. Colin C. Wong, Simon L. I. J. Denil, Jia Nee Foo, Huijia Chen, Angeline Su Ling Tay, Rebecca L. Haines, Mark B. Y. Tang, W. H. Irwin McLean, Aileen Sandilands, Frances J. D. Smith, E. Birgitte Lane, Jianjun Liu, John E. A. Common

Research output: Contribution to journalLetter

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Abstract

Comprehensive sequencing of FLG is a challenging endeavour. We have developed a method using array-based amplicon PCR and NGS for a robust and cost efficient method to analyze this major atopic dermatitis risk factor.

Original languageEnglish
Pages (from-to)814-816
Number of pages3
JournalJournal of Allergy and Clinical Immunology
Volume141
Issue number2
Early online date19 Oct 2017
DOIs
Publication statusPublished - Feb 2018

Keywords

  • Atopic dermatitis
  • Filaggrin
  • Mutations
  • Microfluidics
  • NGS
  • Skin

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    Cite this

    Wong, X. F. C. C., Denil, S. L. I. J., Foo, J. N., Chen, H., Ling Tay, A. S., Haines, R. L., Tang, M. B. Y., McLean, W. H. I., Sandilands, A., Smith, F. J. D., Lane, E. B., Liu, J., & Common, J. E. A. (2018). Array-based sequencing of filaggrin gene for comprehensive detection of disease-associated variants. Journal of Allergy and Clinical Immunology, 141(2), 814-816. https://doi.org/10.1016/j.jaci.2017.10.001