Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines

Robert W. Wiethe; Eugene L Stewart; David H Drewry; David W Gray; Abdul Mehbob; William J Hoekstra

doi:10.1016/j.bmcl.2006.04.055

Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines

Robert W. Wiethe, Eugene L Stewart, David H Drewry, David W Gray, Abdul Mehbob, William J Hoekstra

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

New non-steroidal chemotypes are required for the development of drugs targeting the steroid hormone receptors. The parallel array synthesis of 3-aryl-1,2-diazepines employing solid-supported reagents is described. The resulting compounds demonstrated high affinity binding to the progesterone receptor.

Original language	English
Pages (from-to)	3777-9
Number of pages	3
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	16
Issue number	14
DOIs	https://doi.org/10.1016/j.bmcl.2006.04.055
Publication status	Published - 15 Jul 2006

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10.1016/j.bmcl.2006.04.055

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title = "Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines",

abstract = "New non-steroidal chemotypes are required for the development of drugs targeting the steroid hormone receptors. The parallel array synthesis of 3-aryl-1,2-diazepines employing solid-supported reagents is described. The resulting compounds demonstrated high affinity binding to the progesterone receptor.",

author = "Wiethe, {Robert W.} and Stewart, {Eugene L} and Drewry, {David H} and Gray, {David W} and Abdul Mehbob and Hoekstra, {William J}",

year = "2006",

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T1 - Array synthesis of progesterone receptor antagonists

T2 - 3-aryl-1,2-diazepines

AU - Wiethe, Robert W.

AU - Stewart, Eugene L

AU - Drewry, David H

AU - Gray, David W

AU - Mehbob, Abdul

AU - Hoekstra, William J

PY - 2006/7/15

Y1 - 2006/7/15

N2 - New non-steroidal chemotypes are required for the development of drugs targeting the steroid hormone receptors. The parallel array synthesis of 3-aryl-1,2-diazepines employing solid-supported reagents is described. The resulting compounds demonstrated high affinity binding to the progesterone receptor.

AB - New non-steroidal chemotypes are required for the development of drugs targeting the steroid hormone receptors. The parallel array synthesis of 3-aryl-1,2-diazepines employing solid-supported reagents is described. The resulting compounds demonstrated high affinity binding to the progesterone receptor.

U2 - 10.1016/j.bmcl.2006.04.055

DO - 10.1016/j.bmcl.2006.04.055

M3 - Article

C2 - 16678409

SN - 0960-894X

VL - 16

SP - 3777

EP - 3779

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 14

ER -

Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines

Abstract

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