Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines

Robert W. Wiethe, Eugene L Stewart, David H Drewry, David W Gray, Abdul Mehbob, William J Hoekstra

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)


    New non-steroidal chemotypes are required for the development of drugs targeting the steroid hormone receptors. The parallel array synthesis of 3-aryl-1,2-diazepines employing solid-supported reagents is described. The resulting compounds demonstrated high affinity binding to the progesterone receptor.
    Original languageEnglish
    Pages (from-to)3777-9
    Number of pages3
    JournalBioorganic & Medicinal Chemistry Letters
    Issue number14
    Publication statusPublished - 15 Jul 2006


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