Artificial Egg Activation Using Calcium Ionophore

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Artificial oocyte activation, most commonly using calcium ionophore, is a treatment add-on utilized to avoid recurrence of abnormally low or total failed fertilization following in vitro fertilization/intracytoplasmic sperm injection. It aims to modify defective physiological processes, specifically calcium-mediated cell signaling that are critical to events required for fertilization. Routine application of artificial oocyte activation is neither required nor recommended; however, it represents an invaluable intervention for a subgroup of patients affected by sperm-related oocyte activation deficiency.

Original languageEnglish
Pages (from-to)e5-e11
Number of pages7
JournalSeminars in Reproductive Medicine
Issue number05/06
Early online date10 Mar 2022
Publication statusE-pub ahead of print - 10 Mar 2022


  • ART adjuvant
  • add-on
  • artificial oocyte activation
  • calcium ionophore
  • failed fertilization

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynaecology
  • Physiology (medical)


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