Abstract
Artificial oocyte activation, most commonly using calcium ionophore, is a treatment add-on utilized to avoid recurrence of abnormally low or total failed fertilization following in vitro fertilization/intracytoplasmic sperm injection. It aims to modify defective physiological processes, specifically calcium-mediated cell signaling that are critical to events required for fertilization. Routine application of artificial oocyte activation is neither required nor recommended; however, it represents an invaluable intervention for a subgroup of patients affected by sperm-related oocyte activation deficiency.
| Original language | English |
|---|---|
| Pages (from-to) | e5-e11 |
| Number of pages | 7 |
| Journal | Seminars in Reproductive Medicine |
| Volume | 39 |
| Issue number | 05/06 |
| Early online date | 10 Mar 2022 |
| DOIs | |
| Publication status | E-pub ahead of print - 10 Mar 2022 |
Keywords
- ART adjuvant
- add-on
- artificial oocyte activation
- calcium ionophore
- failed fertilization
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Reproductive Medicine
- Endocrinology
- Obstetrics and Gynaecology
- Physiology (medical)
