Aspirin, nonsteroidal anti-inflammatory drugs, and epistaxis: A regional record linkage case control study

Huey L. Tay, Alexander D. McMahon, Josie M. M. Evans (Lead / Corresponding author), Thomas M. MacDonald

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

To assess the relationship between nonsteroidal anti-inflammatory drugs (NSAIDs) and spontaneous epistaxis in adults over 50 years old, a case control study was carried out by using a record linkage database for the population of Tayside, Scotland, which included 319,465 people. The study group consisted of 326 patients who were hospitalized with epistaxis between May 1989 and December 1992, but who had not previously been hospitalized with this diagnosis. Six community controls and 4 hospital controls, matched for age and sex to each case, were used. Previous exposure to prescribed aspirin and other NSAIDs was investigated. There was a significant association between aspirin exposure and epistaxis when either community or hospital controls were used (p < .001). Patients who had aspirin prescriptions had a relative risk of hospital admission for epistaxis of between 2.17 and 2.75, depending on the control group used. No association between non-aspirin NSAIDs and epistaxis was evident with either control group.

Original languageEnglish
Pages (from-to)671-674
Number of pages4
JournalAnnals of Otology, Rhinology and Laryngology
Volume107
Issue number8
DOIs
Publication statusPublished - 1 Aug 1998

Keywords

  • Aspirin
  • Case control study
  • Epistaxis
  • Nonsteroidal anti-inflammatory drugs

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