TY - JOUR
T1 - Assessment of Ischemic Index in Retinal Vascular Diseases Using Ultra-Wide-Field Fluorescein Angiography
T2 - Single Versus Summarized Image
AU - Franco-Cardenas, Valentina
AU - Shah, Sanket U.
AU - Apap, David
AU - Joseph, Anthony
AU - Heilweil, Gad
AU - Zutis, Kris
AU - Trucco, Emanuele
AU - Hubschman, Jean Pierre
N1 - Funding: Earl and Doris Peterson Fund; The Hess Foundation, Inc.
PY - 2016/4
Y1 - 2016/4
N2 - Background and Objective: To compare a single image with a computer-generated summarized image from the ultra-wide-field fluorescein angiogram (UWFFA) sequence for evaluation of ischemic index (ISI).Materials and Methods: UWFFA sequences from patients with diabetic retinopathy (DR) (n=5), branch retinal vein occlusion (BRVO) (n=5), and central retinal vein occlusion (CRVO) (n=5) were evaluated by six graders. A single image best illustrating retinal non-perfusion was compared to a summarized image generated by computerized superimposition of angiograms. Non-perfused and ungradable retinal areas were outlined and the ISI between the single and summarized images was compared.Results: The mean ISI in the single versus (vs) summarized images was 17% vs 15% in BRVO (p=0.12), 48% vs 48% in CRVO (p=0.67), and 25% vs 23% in DR (p=0.005). Inter-grader agreement of ISI in single versus summarized images was 0.43 vs 0.40 in BRVO, 0.69 vs 0.71 in CRVO, and 0.53 vs 0.34 in DR.Conclusion: Computer-generated summarized images were similar to single images for grading ISI in BRVO and CRVO, but underestimated it in DR.
AB - Background and Objective: To compare a single image with a computer-generated summarized image from the ultra-wide-field fluorescein angiogram (UWFFA) sequence for evaluation of ischemic index (ISI).Materials and Methods: UWFFA sequences from patients with diabetic retinopathy (DR) (n=5), branch retinal vein occlusion (BRVO) (n=5), and central retinal vein occlusion (CRVO) (n=5) were evaluated by six graders. A single image best illustrating retinal non-perfusion was compared to a summarized image generated by computerized superimposition of angiograms. Non-perfused and ungradable retinal areas were outlined and the ISI between the single and summarized images was compared.Results: The mean ISI in the single versus (vs) summarized images was 17% vs 15% in BRVO (p=0.12), 48% vs 48% in CRVO (p=0.67), and 25% vs 23% in DR (p=0.005). Inter-grader agreement of ISI in single versus summarized images was 0.43 vs 0.40 in BRVO, 0.69 vs 0.71 in CRVO, and 0.53 vs 0.34 in DR.Conclusion: Computer-generated summarized images were similar to single images for grading ISI in BRVO and CRVO, but underestimated it in DR.
KW - Automated retinal image analysis
KW - branch retinal vein occlusion
KW - capillary dropout
KW - central retinal vein occlusion
KW - diabetic retinopathy
KW - fluorescein angiography
KW - inter-grader agreement
KW - ischemic index
KW - non-perfusion
KW - retinal ischemia
UR - http://www.scopus.com/inward/record.url?scp=84963623716&partnerID=8YFLogxK
U2 - 10.3109/08820538.2015.1095304
DO - 10.3109/08820538.2015.1095304
M3 - Article
C2 - 27077942
AN - SCOPUS:84963623716
SN - 0882-0538
VL - 32
SP - 353
EP - 357
JO - Seminars in Ophthalmology
JF - Seminars in Ophthalmology
ER -