Assessment of Ischemic Index in Retinal Vascular Diseases Using Ultra-Wide-Field Fluorescein Angiography: Single Versus Summarized Image

TY - JOUR

T1 - Assessment of Ischemic Index in Retinal Vascular Diseases Using Ultra-Wide-Field Fluorescein Angiography

T2 - Single Versus Summarized Image

AU - Franco-Cardenas, Valentina

AU - Shah, Sanket U.

AU - Apap, David

AU - Joseph, Anthony

AU - Heilweil, Gad

AU - Zutis, Kris

AU - Trucco, Emanuele

AU - Hubschman, Jean Pierre

N1 - Funding: Earl and Doris Peterson Fund; The Hess Foundation, Inc.

PY - 2016/4

Y1 - 2016/4

N2 - Background and Objective: To compare a single image with a computer-generated summarized image from the ultra-wide-field fluorescein angiogram (UWFFA) sequence for evaluation of ischemic index (ISI).Materials and Methods: UWFFA sequences from patients with diabetic retinopathy (DR) (n=5), branch retinal vein occlusion (BRVO) (n=5), and central retinal vein occlusion (CRVO) (n=5) were evaluated by six graders. A single image best illustrating retinal non-perfusion was compared to a summarized image generated by computerized superimposition of angiograms. Non-perfused and ungradable retinal areas were outlined and the ISI between the single and summarized images was compared.Results: The mean ISI in the single versus (vs) summarized images was 17% vs 15% in BRVO (p=0.12), 48% vs 48% in CRVO (p=0.67), and 25% vs 23% in DR (p=0.005). Inter-grader agreement of ISI in single versus summarized images was 0.43 vs 0.40 in BRVO, 0.69 vs 0.71 in CRVO, and 0.53 vs 0.34 in DR.Conclusion: Computer-generated summarized images were similar to single images for grading ISI in BRVO and CRVO, but underestimated it in DR.

AB - Background and Objective: To compare a single image with a computer-generated summarized image from the ultra-wide-field fluorescein angiogram (UWFFA) sequence for evaluation of ischemic index (ISI).Materials and Methods: UWFFA sequences from patients with diabetic retinopathy (DR) (n=5), branch retinal vein occlusion (BRVO) (n=5), and central retinal vein occlusion (CRVO) (n=5) were evaluated by six graders. A single image best illustrating retinal non-perfusion was compared to a summarized image generated by computerized superimposition of angiograms. Non-perfused and ungradable retinal areas were outlined and the ISI between the single and summarized images was compared.Results: The mean ISI in the single versus (vs) summarized images was 17% vs 15% in BRVO (p=0.12), 48% vs 48% in CRVO (p=0.67), and 25% vs 23% in DR (p=0.005). Inter-grader agreement of ISI in single versus summarized images was 0.43 vs 0.40 in BRVO, 0.69 vs 0.71 in CRVO, and 0.53 vs 0.34 in DR.Conclusion: Computer-generated summarized images were similar to single images for grading ISI in BRVO and CRVO, but underestimated it in DR.

KW - Automated retinal image analysis

KW - branch retinal vein occlusion

KW - capillary dropout

KW - central retinal vein occlusion

KW - diabetic retinopathy

KW - fluorescein angiography

KW - inter-grader agreement

KW - ischemic index

KW - non-perfusion

KW - retinal ischemia

UR - https://www.scopus.com/pages/publications/84963623716

U2 - 10.3109/08820538.2015.1095304

DO - 10.3109/08820538.2015.1095304

M3 - Article

C2 - 27077942

AN - SCOPUS:84963623716

SN - 0882-0538

VL - 32

SP - 353

EP - 357

JO - Seminars in Ophthalmology

JF - Seminars in Ophthalmology

ER -