Assessment of p53 protein expression in normal, benign, and malignant oral mucosa

Graham R. Ogden; Roy A. Kiddie; Declan P. Lunny; David P. Lane

doi:10.1002/path.1711660411

Assessment of p53 protein expression in normal, benign, and malignant oral mucosa

Graham R. Ogden
, Roy A. Kiddie
, Declan P. Lunny
, David P. Lane

Research output: Contribution to journal › Article › peer-review

169 Citations (Scopus)

Abstract

Recent studies have shown the accumulation of high levels of p53 protein to be associated with malignant disease, within a range of tissues. This paper assesses p53 expression in oral mucosal disease. Biopsies were obtained from a range of oral disorders which included normal, benign, premalignant, and malignant oral tissue. In addition, oral smears were obtained from a limited number of patients with biopsy-proven oral cancer. Expression of the p53 protein was assessed using the polyclonal antibody CM1, together with a standard immunoperoxidase technique. A total of 37 oral cancers were assessed, of which 20 were found to express the p53 protein (54 per cent of cases). The p53 protein was not identified in normal, benign, or premalignant oral mucosa (54 cases). The identification of p53 within biopsies of oral mucosal lesions would appear to correlate with oral malignancy.

Original language	English
Pages (from-to)	389-394
Number of pages	6
Journal	Journal of Pathology
Volume	166
Issue number	4
DOIs	https://doi.org/10.1002/path.1711660411
Publication status	Published - Apr 1992

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title = "Assessment of p53 protein expression in normal, benign, and malignant oral mucosa",

abstract = "Recent studies have shown the accumulation of high levels of p53 protein to be associated with malignant disease, within a range of tissues. This paper assesses p53 expression in oral mucosal disease. Biopsies were obtained from a range of oral disorders which included normal, benign, premalignant, and malignant oral tissue. In addition, oral smears were obtained from a limited number of patients with biopsy-proven oral cancer. Expression of the p53 protein was assessed using the polyclonal antibody CM1, together with a standard immunoperoxidase technique. A total of 37 oral cancers were assessed, of which 20 were found to express the p53 protein (54 per cent of cases). The p53 protein was not identified in normal, benign, or premalignant oral mucosa (54 cases). The identification of p53 within biopsies of oral mucosal lesions would appear to correlate with oral malignancy.",

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T1 - Assessment of p53 protein expression in normal, benign, and malignant oral mucosa

AU - Ogden, Graham R.

AU - Kiddie, Roy A.

AU - Lunny, Declan P.

AU - Lane, David P.

PY - 1992/4

Y1 - 1992/4

N2 - Recent studies have shown the accumulation of high levels of p53 protein to be associated with malignant disease, within a range of tissues. This paper assesses p53 expression in oral mucosal disease. Biopsies were obtained from a range of oral disorders which included normal, benign, premalignant, and malignant oral tissue. In addition, oral smears were obtained from a limited number of patients with biopsy-proven oral cancer. Expression of the p53 protein was assessed using the polyclonal antibody CM1, together with a standard immunoperoxidase technique. A total of 37 oral cancers were assessed, of which 20 were found to express the p53 protein (54 per cent of cases). The p53 protein was not identified in normal, benign, or premalignant oral mucosa (54 cases). The identification of p53 within biopsies of oral mucosal lesions would appear to correlate with oral malignancy.

AB - Recent studies have shown the accumulation of high levels of p53 protein to be associated with malignant disease, within a range of tissues. This paper assesses p53 expression in oral mucosal disease. Biopsies were obtained from a range of oral disorders which included normal, benign, premalignant, and malignant oral tissue. In addition, oral smears were obtained from a limited number of patients with biopsy-proven oral cancer. Expression of the p53 protein was assessed using the polyclonal antibody CM1, together with a standard immunoperoxidase technique. A total of 37 oral cancers were assessed, of which 20 were found to express the p53 protein (54 per cent of cases). The p53 protein was not identified in normal, benign, or premalignant oral mucosa (54 cases). The identification of p53 within biopsies of oral mucosal lesions would appear to correlate with oral malignancy.

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DO - 10.1002/path.1711660411

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SP - 389

EP - 394

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JF - Journal of Pathology

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ER -

Assessment of p53 protein expression in normal, benign, and malignant oral mucosa

Abstract

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