Assessment of proximal pulmonary arterial stiffness using magnetic resonance imaging: effects of technique, age and exercise

Jonathan R. Weir-McCall, Anu Kamalasanan, Deidre B. Cassidy, Allan D. Struthers, Brian J. Lipworth, J. Graeme Houston (Lead / Corresponding author)

Research output: Contribution to journalArticle

125 Downloads (Pure)


Introduction: To compare the reproducibility of pulmonary pulse wave velocity (PWV) techniques, and the effects of age and exercise on these.

Methods: 10 young healthy volunteers (YHV) and 20 older healthy volunteers (OHV) with no cardiac or lung condition were recruited. High temporal resolution phase contrast sequences were performed through the main pulmonary arteries (MPAs), right pulmonary arteries (RPAs) and left pulmonary arteries (LPAs), while high spatial resolution sequences were obtained through the MPA. YHV underwent 2 MRIs 6 months apart with the sequences repeated during exercise. OHV underwent an MRI scan with on-table repetition. PWV was calculated using the transit time (TT) and flow area techniques (QA). 3 methods for calculating QA PWV were compared.

Results: PWV did not differ between the two age groups (YHV 2.4±0.3/ms, OHV 2.9±0.2/ms, p=0.1). Using a high temporal resolution sequence through the RPA using the QA accounting for wave reflections yielded consistently better within-scan, interscan, intraobserver and interobserver reproducibility. Exercise did not result in a change in either TT PWV (mean (95% CI) of the differences: −0.42 (−1.2 to 0.4), p=0.24) or QA PWV (mean (95% CI) of the differences: 0.10 (−0.5 to 0.9), p=0.49) despite a significant rise in heart rate (65±2 to 87±3, p<0.0001), blood pressure (113/68 to 130/84, p<0.0001) and cardiac output (5.4±0.4 to 6.7±0.6 L/min, p=0.004).

Conclusions: QA PWV performed through the RPA using a high temporal resolution sequence accounting for wave reflections yields the most reproducible measurements of pulmonary PWV.
Original languageEnglish
Article numbere000149
Number of pages10
JournalBMJ Open Respiratory Research
Issue number1
Publication statusPublished - 7 Oct 2016

Fingerprint Dive into the research topics of 'Assessment of proximal pulmonary arterial stiffness using magnetic resonance imaging: effects of technique, age and exercise'. Together they form a unique fingerprint.

  • Profiles

    No photo of Graeme Houston

    Houston, Graeme

    Person: Academic

    Cite this