Assessment of pseudomonas aeruginosa N-5,N-10-methylenetetrahydrofolate dehydrogenase - cyclohydrolase as a potential antibacterial drug target

Keyphrases

• Methylenetetrahydrofolate Reductase (MTHFR) 100%
• Pseudomonas Aeruginosa (P. aeruginosa) 100%
• Antibacterial Target 100%
• Cyclohydrolase 100%
• Drug Discovery 66%
• Human Enzymes 66%
• High Efficiency 33%
• Realist Evaluation 33%
• Enzyme Inhibition 33%
• Gram-negative Bacteria 33%
• Putative Drug Targets 33%
• Structural Information 33%
• Compound Library 33%
• Screening Campaign 33%
• Biological Data 33%
• Selective Inhibition 33%
• Bifunctional Enzyme 33%
• Angstrom 33%
• Comprehensive Assessment 33%
• Production System 33%
• Purification Process 33%
• Druggability 33%
• Lead Molecules 33%
• Enzyme Structure 33%
• Ligand Complexes 33%
• Recombinant Protein Production 33%
• Bacterial Enzymes 33%
• New Antibacterials 33%
• Antibacterial Drugs 33%
• Commercial Chemicals 33%
• High-throughput Enzyme Assay 33%
• Differential Scanning Fluorimetry 33%

Biochemistry, Genetics and Molecular Biology

• Enzyme 100%
• Oxidoreductase 100%
• Pseudomonas aeruginosa 100%
• Dehydrogenase 100%
• Crystal Structure 25%
• Copurification 25%
• DNA Template 25%
• Recombinant Protein 25%
• Gram Negative Bacterium 25%
• Enzyme Assay 25%
• Enzyme Structure 25%
• Enzyme Inhibition 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Antiinfective Agent 100%
• Pseudomonas aeruginosa 100%
• Methylenetetrahydrofolate Dehydrogenase 100%
• Drug Discovery 66%
• Enzyme Inhibition 33%
• Recombinant Protein 33%
• Gram Negative Bacterium 33%