Assessment of pseudomonas aeruginosa N-5,N-10-methylenetetrahydrofolate dehydrogenase - cyclohydrolase as a potential antibacterial drug target

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• Finished

  Aref#d: 19815. Wellcome Trust Centre for Drug Discovery (Strategic Award)

  Fairlamb, A. (Investigator), Ferguson, M. (Investigator) & Frearson, J. (Investigator)

  1/01/08 → 31/12/12

  Project: Research

  • Trypanosoma Brucei 100%
  • Enzyme 67%
  • Parasite 61%
  • Enzymes 53%
  • Drug Discovery 39%

• Aref#d: 19401. Structure, specificity and mechanism of biosynthetic enzymes in trypanosomatids and inhibitor discovery of essential microbial functions (Programme Grant)

  Hunter, B. (Investigator)

  1/11/07 → 31/12/13

  Project: Research

  • Enzyme 100%
  • Crystal Structure 82%
  • Active Site 63%
  • Enzymes 57%
  • Oxidoreductase 48%