Assessment of tumour vascularity as a prognostic factor in lymph node negative invasive breast cancer

M E Van Hoef, W F Knox, S S Dhesi, A Howell, A M Schor

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Abstract

The association between tumour vascularity and relapse was examined in 93 patients with lymph node negative (LNN) invasive breast cancer. Factor VIII-related antibody was used to stain the microvessels. Vascularity was defined by the number of vessels per field counted in the area of highest vascular density at 100 x magnification. These vascular counts were divided into three groups of vascular density (group I: < 67, group 2: 68-100, group 3: > 101 vessels/field). Cross-tabulation analysis revealed a significant relationship between vascular density and tumour grade (P = 0.027). No association was found between vascularity and tumour size, tumour type, age or menopausal status. Survival analysis showed no association between vascularity and relapse-free (P = 0.92) or overall survival (P = 0.99). Significant associations between tumour grade and relapse-free (P = 0.0048) and overall survival (P = 0.0064) and between tumour size at the cut off of 15 mm diameter and relapse-free (P = 0.0097) and overall survival (P = 0.0271) were found. When grade was taken into account the effect of tumour size became non-significant (P = 0.059). Our results suggest that assessment of vascularity is not an independent prognostic factor in LNN invasive breast cancer.

Original languageEnglish
Pages (from-to)1141-5
Number of pages5
JournalEuropean Journal of Cancer
Volume29
Issue number8
DOIs
Publication statusPublished - 1993

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Keywords

  • Adult
  • Aged
  • Breast Neoplasms/blood supply
  • Capillaries/pathology
  • Carcinoma, Intraductal, Noninfiltrating/blood supply
  • Female
  • Humans
  • Lymph Nodes/pathology
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Prognosis
  • Survival Analysis

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