ASSIGN score and cancer risk in the Scottish Heart Health Extended Cohort (SHHEC) study

Catherine A. Fitton; Mark Woodward; Jill Belch

doi:10.1038/s44276-024-00102-5

ASSIGN score and cancer risk in the Scottish Heart Health Extended Cohort (SHHEC) study

Catherine A. Fitton
, Mark Woodward
, Jill Belch (Lead / Corresponding author)

Cardiovascular Research

Research output: Contribution to journal › Article › peer-review

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Abstract

Background
The aim of this work was to determine whether the ASSIGN cardiovascular disease (CVD) score, a 10-year CVD risk score used in primary care in Scotland, could additionally detect cancer risk.

Methods
18,107 participants were recruited to the Scottish Heart Health Extended Cohort (SHHEC) study between 1982 and 1995. Information on health and lifestyle were collected, along with blood and urine, and participants were followed up via record linkage to 2017. Cox proportional hazards were used to estimate HRs (95% CIs) for time to cancer diagnosis.

Results
A total of 5046 cases of cancer were reported during the follow up period. ASSIGN was significantly associated with a diagnosis of cancer, with a 2.3–3.4% increase in risk of cancer per 1-point increase of ASSIGN. The components of ASSIGN predominantly associated with the risk of cancer were age (HR 1.52; 95% CI 1.48–1.56, cholesterol level (HR 1.11; 95% CI 1.08–1.13), diabetes status (HR 1.24; 95% CI 1.01–1.53), and systolic blood pressure (HR 1.16; 95% CI 1.13–1.19).

Conclusion
ASSIGN could be used not only to predict CVD, but also to predict cancer risk in patients. This needs to be validated in further cohorts.

Original language	English
Article number	75
Number of pages	5
Journal	BJC Reports
Volume	2
DOIs	https://doi.org/10.1038/s44276-024-00102-5
Publication status	Published - 1 Oct 2024

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SDG 3 Good Health and Well-being

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Scottish Heart Health Extended Cohort (SHHEC)
Belch, J. (Creator), University of Dundee, 2024
https://publichealthscotland.scot/resources-and-tools/health-intelligence-and-data-management/electronic-data-research-and-innovation-service-edris/services-we-offer/
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title = "ASSIGN score and cancer risk in the Scottish Heart Health Extended Cohort (SHHEC) study",

abstract = "Background The aim of this work was to determine whether the ASSIGN cardiovascular disease (CVD) score, a 10-year CVD risk score used in primary care in Scotland, could additionally detect cancer risk. Methods 18,107 participants were recruited to the Scottish Heart Health Extended Cohort (SHHEC) study between 1982 and 1995. Information on health and lifestyle were collected, along with blood and urine, and participants were followed up via record linkage to 2017. Cox proportional hazards were used to estimate HRs (95\% CIs) for time to cancer diagnosis. Results A total of 5046 cases of cancer were reported during the follow up period. ASSIGN was significantly associated with a diagnosis of cancer, with a 2.3–3.4\% increase in risk of cancer per 1-point increase of ASSIGN. The components of ASSIGN predominantly associated with the risk of cancer were age (HR 1.52; 95\% CI 1.48–1.56, cholesterol level (HR 1.11; 95\% CI 1.08–1.13), diabetes status (HR 1.24; 95\% CI 1.01–1.53), and systolic blood pressure (HR 1.16; 95\% CI 1.13–1.19). Conclusion ASSIGN could be used not only to predict CVD, but also to predict cancer risk in patients. This needs to be validated in further cohorts.",

author = "Fitton, \{Catherine A.\} and Mark Woodward and Jill Belch",

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year = "2024",

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day = "1",

doi = "10.1038/s44276-024-00102-5",

language = "English",

volume = "2",

journal = "BJC Reports",

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TY - JOUR

T1 - ASSIGN score and cancer risk in the Scottish Heart Health Extended Cohort (SHHEC) study

AU - Fitton, Catherine A.

AU - Woodward, Mark

AU - Belch, Jill

PY - 2024/10/1

Y1 - 2024/10/1

N2 - Background The aim of this work was to determine whether the ASSIGN cardiovascular disease (CVD) score, a 10-year CVD risk score used in primary care in Scotland, could additionally detect cancer risk. Methods 18,107 participants were recruited to the Scottish Heart Health Extended Cohort (SHHEC) study between 1982 and 1995. Information on health and lifestyle were collected, along with blood and urine, and participants were followed up via record linkage to 2017. Cox proportional hazards were used to estimate HRs (95% CIs) for time to cancer diagnosis. Results A total of 5046 cases of cancer were reported during the follow up period. ASSIGN was significantly associated with a diagnosis of cancer, with a 2.3–3.4% increase in risk of cancer per 1-point increase of ASSIGN. The components of ASSIGN predominantly associated with the risk of cancer were age (HR 1.52; 95% CI 1.48–1.56, cholesterol level (HR 1.11; 95% CI 1.08–1.13), diabetes status (HR 1.24; 95% CI 1.01–1.53), and systolic blood pressure (HR 1.16; 95% CI 1.13–1.19). Conclusion ASSIGN could be used not only to predict CVD, but also to predict cancer risk in patients. This needs to be validated in further cohorts.

AB - Background The aim of this work was to determine whether the ASSIGN cardiovascular disease (CVD) score, a 10-year CVD risk score used in primary care in Scotland, could additionally detect cancer risk. Methods 18,107 participants were recruited to the Scottish Heart Health Extended Cohort (SHHEC) study between 1982 and 1995. Information on health and lifestyle were collected, along with blood and urine, and participants were followed up via record linkage to 2017. Cox proportional hazards were used to estimate HRs (95% CIs) for time to cancer diagnosis. Results A total of 5046 cases of cancer were reported during the follow up period. ASSIGN was significantly associated with a diagnosis of cancer, with a 2.3–3.4% increase in risk of cancer per 1-point increase of ASSIGN. The components of ASSIGN predominantly associated with the risk of cancer were age (HR 1.52; 95% CI 1.48–1.56, cholesterol level (HR 1.11; 95% CI 1.08–1.13), diabetes status (HR 1.24; 95% CI 1.01–1.53), and systolic blood pressure (HR 1.16; 95% CI 1.13–1.19). Conclusion ASSIGN could be used not only to predict CVD, but also to predict cancer risk in patients. This needs to be validated in further cohorts.

U2 - 10.1038/s44276-024-00102-5

DO - 10.1038/s44276-024-00102-5

M3 - Article

C2 - 39516549

VL - 2

JO - BJC Reports

JF - BJC Reports

M1 - 75

ER -

ASSIGN score and cancer risk in the Scottish Heart Health Extended Cohort (SHHEC) study

Abstract

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Scottish Heart Health Extended Cohort (SHHEC)

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