Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

A Kaas; C Pfleger; A V Kharagjitsingh; N C Schloot; L Hansen; K Buschard; B P C Koeleman; B O Roep; H B Mortensen; B Z Alizadeh; S. A. Greene; on behalf of the Hvidoere Study Group on Childhood Diabetes

doi:10.1111/j.1464-5491.2011.03544.x

Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

A Kaas, C Pfleger, A V Kharagjitsingh, N C Schloot, L Hansen, K Buschard, B P C Koeleman, B O Roep, H B Mortensen, B Z Alizadeh, S. A. Greene, on behalf of the Hvidoere Study Group on Childhood Diabetes

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Diabet. Med. 29, 734-741 (2012) ABSTRACT: Aims The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFN?) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes. Methods Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFN? gene were genotyped and serum levels of IL-10 and IFN? were measured at 1, 6 and 12 months. Results IL-10 decreased (P

Original language	English
Pages (from-to)	734-741
Number of pages	8
Journal	Diabetic Medicine
Volume	29
Issue number	6
DOIs	https://doi.org/10.1111/j.1464-5491.2011.03544.x
Publication status	Published - 2012

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Kaas, A., Pfleger, C., Kharagjitsingh, A. V., Schloot, N. C., Hansen, L., Buschard, K., Koeleman, B. P. C., Roep, B. O., Mortensen, H. B., Alizadeh, B. Z., Greene, S. A., & on behalf of the Hvidoere Study Group on Childhood Diabetes (2012). Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes. Diabetic Medicine, 29(6), 734-741. https://doi.org/10.1111/j.1464-5491.2011.03544.x

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title = "Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes",

abstract = "Diabet. Med. 29, 734-741 (2012) ABSTRACT: Aims The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFN?) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes. Methods Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFN? gene were genotyped and serum levels of IL-10 and IFN? were measured at 1, 6 and 12 months. Results IL-10 decreased (P ",

author = "A Kaas and C Pfleger and Kharagjitsingh, {A V} and Schloot, {N C} and L Hansen and K Buschard and Koeleman, {B P C} and Roep, {B O} and Mortensen, {H B} and Alizadeh, {B Z} and Greene, {S. A.} and {on behalf of the Hvidoere Study Group on Childhood Diabetes}",

note = "{\textcopyright} 2011 The Authors. Diabetic Medicine {\textcopyright} 2011 Diabetes UK.",

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Kaas, A, Pfleger, C, Kharagjitsingh, AV, Schloot, NC, Hansen, L, Buschard, K, Koeleman, BPC, Roep, BO, Mortensen, HB, Alizadeh, BZ, Greene, SA & on behalf of the Hvidoere Study Group on Childhood Diabetes 2012, 'Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes', Diabetic Medicine, vol. 29, no. 6, pp. 734-741. https://doi.org/10.1111/j.1464-5491.2011.03544.x

TY - JOUR

T1 - Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

AU - Kaas, A

AU - Pfleger, C

AU - Kharagjitsingh, A V

AU - Schloot, N C

AU - Hansen, L

AU - Buschard, K

AU - Koeleman, B P C

AU - Roep, B O

AU - Mortensen, H B

AU - Alizadeh, B Z

AU - Greene, S. A.

AU - on behalf of the Hvidoere Study Group on Childhood Diabetes

PY - 2012

Y1 - 2012

N2 - Diabet. Med. 29, 734-741 (2012) ABSTRACT: Aims The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFN?) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes. Methods Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFN? gene were genotyped and serum levels of IL-10 and IFN? were measured at 1, 6 and 12 months. Results IL-10 decreased (P

AB - Diabet. Med. 29, 734-741 (2012) ABSTRACT: Aims The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFN?) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes. Methods Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFN? gene were genotyped and serum levels of IL-10 and IFN? were measured at 1, 6 and 12 months. Results IL-10 decreased (P

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DO - 10.1111/j.1464-5491.2011.03544.x

M3 - Article

C2 - 22150609

SN - 1464-5491

VL - 29

SP - 734

EP - 741

JO - Diabetic Medicine

JF - Diabetic Medicine

IS - 6

ER -

Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

Abstract

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