Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

A Kaas, C Pfleger, A V Kharagjitsingh, N C Schloot, L Hansen, K Buschard, B P C Koeleman, B O Roep, H B Mortensen, B Z Alizadeh, S. A. Greene, on behalf of the Hvidoere Study Group on Childhood Diabetes

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    Abstract

    Diabet. Med. 29, 734-741 (2012) ABSTRACT: Aims The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFN?) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes. Methods Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFN? gene were genotyped and serum levels of IL-10 and IFN? were measured at 1, 6 and 12 months. Results IL-10 decreased (P
    Original languageEnglish
    Pages (from-to)734-741
    Number of pages8
    JournalDiabetic Medicine
    Volume29
    Issue number6
    DOIs
    Publication statusPublished - 2012

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    Kaas, A., Pfleger, C., Kharagjitsingh, A. V., Schloot, N. C., Hansen, L., Buschard, K., Koeleman, B. P. C., Roep, B. O., Mortensen, H. B., Alizadeh, B. Z., Greene, S. A., & on behalf of the Hvidoere Study Group on Childhood Diabetes (2012). Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes. Diabetic Medicine, 29(6), 734-741. https://doi.org/10.1111/j.1464-5491.2011.03544.x