OBJECTIVE-To describe the association of BMI with mortality in patients diagnosed with type 2 diabetes.
RESEARCH DESIGN AND METHODS-Using records of 106,640 patients in Scotland, we investigated the association between BMI recorded around the diagnosis of type 2 diabetes mellitus (T2DM) and mortality using Cox proportional hazards regression adjusted for age and smoking status, with BMI 25 to
RESULTS-A total of 9,631 deaths occurred between 2001 and 2007. Compared with the reference group, mortality risk was higher in patients with BMI 20 to = 35 kg/m(2) (for example, 1.70 [1.24-2.34] in men and 1.81 [1.46-2.24] in women for BMI 45 to 30 kg/m(2) by 24% (15-35%) in men and 23%(14-32%) in women, but was lower below this threshold. The results were similar after further adjustment for HbA(1c), year of diagnosis, lipids, blood pressure, and socioeconomic status.
CONCLUSIONS-Patients categorized as normal weight or obese with T2DM within a year of diagnosis of T2DM exhibit variably higher mortality outcomes compared with the overweight group, confirming a U-shaped association of BMI with mortality. Whether weight loss interventions reduce mortality in all T2DM patients requires study. Diabetes Care 36:887-893, 2013
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