Association Between BMI Measured Within a Year After Diagnosis of Type 2 Diabetes and Mortality

Jennifer Logue; Jeremy J. Walker; Graham Leese; Robert Lindsay; John McKnight; Andrew Morris; Sam Philip; Sarah Wild; Naveed Sattar; Scottish Diabetes Research Network Epidemiology Group

doi:10.2337/dc12-0944

Association Between BMI Measured Within a Year After Diagnosis of Type 2 Diabetes and Mortality

Jennifer Logue, Jeremy J. Walker, Graham Leese, Robert Lindsay, John McKnight, Andrew Morris, Sam Philip, Sarah Wild, Naveed Sattar, Scottish Diabetes Research Network Epidemiology Group

Research output: Contribution to journal › Article › peer-review

115 Citations (Scopus)

Abstract

OBJECTIVE-To describe the association of BMI with mortality in patients diagnosed with type 2 diabetes.

RESEARCH DESIGN AND METHODS-Using records of 106,640 patients in Scotland, we investigated the association between BMI recorded around the diagnosis of type 2 diabetes mellitus (T2DM) and mortality using Cox proportional hazards regression adjusted for age and smoking status, with BMI 25 to

RESULTS-A total of 9,631 deaths occurred between 2001 and 2007. Compared with the reference group, mortality risk was higher in patients with BMI 20 to = 35 kg/m(2) (for example, 1.70 [1.24-2.34] in men and 1.81 [1.46-2.24] in women for BMI 45 to 30 kg/m(2) by 24% (15-35%) in men and 23%(14-32%) in women, but was lower below this threshold. The results were similar after further adjustment for HbA(1c), year of diagnosis, lipids, blood pressure, and socioeconomic status.

CONCLUSIONS-Patients categorized as normal weight or obese with T2DM within a year of diagnosis of T2DM exhibit variably higher mortality outcomes compared with the overweight group, confirming a U-shaped association of BMI with mortality. Whether weight loss interventions reduce mortality in all T2DM patients requires study. Diabetes Care 36:887-893, 2013

Original language	English
Pages (from-to)	887-893
Number of pages	7
Journal	Diabetes Care
Volume	36
Issue number	4
DOIs	https://doi.org/10.2337/dc12-0944
Publication status	Published - Apr 2013

Keywords

RISK-FACTORS
CORONARY HEART-DISEASE
FOLLOW-UP
MODEL
DEATH
HEALTH
COHORT
BODY-MASS-INDEX
ADULTS
OBESITY

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2337/dc12-0944

Cite this

@article{210956f4ebc842edb1836450b6a317ad,

title = "Association Between BMI Measured Within a Year After Diagnosis of Type 2 Diabetes and Mortality",

abstract = "OBJECTIVE-To describe the association of BMI with mortality in patients diagnosed with type 2 diabetes.RESEARCH DESIGN AND METHODS-Using records of 106,640 patients in Scotland, we investigated the association between BMI recorded around the diagnosis of type 2 diabetes mellitus (T2DM) and mortality using Cox proportional hazards regression adjusted for age and smoking status, with BMI 25 to RESULTS-A total of 9,631 deaths occurred between 2001 and 2007. Compared with the reference group, mortality risk was higher in patients with BMI 20 to = 35 kg/m(2) (for example, 1.70 [1.24-2.34] in men and 1.81 [1.46-2.24] in women for BMI 45 to 30 kg/m(2) by 24% (15-35%) in men and 23%(14-32%) in women, but was lower below this threshold. The results were similar after further adjustment for HbA(1c), year of diagnosis, lipids, blood pressure, and socioeconomic status.CONCLUSIONS-Patients categorized as normal weight or obese with T2DM within a year of diagnosis of T2DM exhibit variably higher mortality outcomes compared with the overweight group, confirming a U-shaped association of BMI with mortality. Whether weight loss interventions reduce mortality in all T2DM patients requires study. Diabetes Care 36:887-893, 2013",

keywords = "RISK-FACTORS, CORONARY HEART-DISEASE, FOLLOW-UP, MODEL, DEATH, HEALTH, COHORT, BODY-MASS-INDEX, ADULTS, OBESITY",

author = "Jennifer Logue and Walker, {Jeremy J.} and Graham Leese and Robert Lindsay and John McKnight and Andrew Morris and Sam Philip and Sarah Wild and Naveed Sattar and {Scottish Diabetes Research Network Epidemiology Group}",

year = "2013",

month = apr,

doi = "10.2337/dc12-0944",

language = "English",

volume = "36",

pages = "887--893",

journal = "Diabetes Care",

issn = "0149-5992",

publisher = "American Diabetes Association Inc.",

number = "4",

}

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T1 - Association Between BMI Measured Within a Year After Diagnosis of Type 2 Diabetes and Mortality

AU - Logue, Jennifer

AU - Walker, Jeremy J.

AU - Leese, Graham

AU - Lindsay, Robert

AU - McKnight, John

AU - Morris, Andrew

AU - Philip, Sam

AU - Wild, Sarah

AU - Sattar, Naveed

AU - Scottish Diabetes Research Network Epidemiology Group

PY - 2013/4

Y1 - 2013/4

N2 - OBJECTIVE-To describe the association of BMI with mortality in patients diagnosed with type 2 diabetes.RESEARCH DESIGN AND METHODS-Using records of 106,640 patients in Scotland, we investigated the association between BMI recorded around the diagnosis of type 2 diabetes mellitus (T2DM) and mortality using Cox proportional hazards regression adjusted for age and smoking status, with BMI 25 to RESULTS-A total of 9,631 deaths occurred between 2001 and 2007. Compared with the reference group, mortality risk was higher in patients with BMI 20 to = 35 kg/m(2) (for example, 1.70 [1.24-2.34] in men and 1.81 [1.46-2.24] in women for BMI 45 to 30 kg/m(2) by 24% (15-35%) in men and 23%(14-32%) in women, but was lower below this threshold. The results were similar after further adjustment for HbA(1c), year of diagnosis, lipids, blood pressure, and socioeconomic status.CONCLUSIONS-Patients categorized as normal weight or obese with T2DM within a year of diagnosis of T2DM exhibit variably higher mortality outcomes compared with the overweight group, confirming a U-shaped association of BMI with mortality. Whether weight loss interventions reduce mortality in all T2DM patients requires study. Diabetes Care 36:887-893, 2013

AB - OBJECTIVE-To describe the association of BMI with mortality in patients diagnosed with type 2 diabetes.RESEARCH DESIGN AND METHODS-Using records of 106,640 patients in Scotland, we investigated the association between BMI recorded around the diagnosis of type 2 diabetes mellitus (T2DM) and mortality using Cox proportional hazards regression adjusted for age and smoking status, with BMI 25 to RESULTS-A total of 9,631 deaths occurred between 2001 and 2007. Compared with the reference group, mortality risk was higher in patients with BMI 20 to = 35 kg/m(2) (for example, 1.70 [1.24-2.34] in men and 1.81 [1.46-2.24] in women for BMI 45 to 30 kg/m(2) by 24% (15-35%) in men and 23%(14-32%) in women, but was lower below this threshold. The results were similar after further adjustment for HbA(1c), year of diagnosis, lipids, blood pressure, and socioeconomic status.CONCLUSIONS-Patients categorized as normal weight or obese with T2DM within a year of diagnosis of T2DM exhibit variably higher mortality outcomes compared with the overweight group, confirming a U-shaped association of BMI with mortality. Whether weight loss interventions reduce mortality in all T2DM patients requires study. Diabetes Care 36:887-893, 2013

KW - RISK-FACTORS

KW - CORONARY HEART-DISEASE

KW - FOLLOW-UP

KW - MODEL

KW - DEATH

KW - HEALTH

KW - COHORT

KW - BODY-MASS-INDEX

KW - ADULTS

KW - OBESITY

U2 - 10.2337/dc12-0944

DO - 10.2337/dc12-0944

M3 - Article

SN - 0149-5992

VL - 36

SP - 887

EP - 893

JO - Diabetes Care

JF - Diabetes Care

IS - 4

ER -

Association Between BMI Measured Within a Year After Diagnosis of Type 2 Diabetes and Mortality

Abstract

Keywords

UN SDGs

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