Association between cognition and gene polymorphisms involved in thrombosis and haemostasis

Terence J. Quinn (Lead / Corresponding author), Jahad Alghamdi, Sandosh Padmanabhan, David J. Porteous, Blair H. Smith, Lynne Hocking, Ian J. Deary, John Gallacher, Martina Messow, David J. Stott

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    Abstract

    An association between blood markers of thrombosis and haemostasis and cognitive decline has been described. These results may be confounded by lifestyle and environmental factors. We used a Mendelian randomisation approach to describe the association between thrombosis/haemostasis genotypes and cognition. We studied the genetic variants (single nucleotide polymorphisms) of circulating markers of thrombosis and haemostasis. Our chosen blood factors and associated polymorphisms were D-dimer [rs12029080], fibrinogen [rs1800789], plasminogen activator inhibitor [rs2227631], and von Willebrand factor [rs1063857]. We described association with multidomain cognitive test scores using data from the Scottish Family Health Study. Cognitive data were analysed for individual tests and combined to give a general cognitive factor. In 20,288 subjects, we found no evidence of association between cognitive function (individual tests and combined scores) and any of the above-mentioned single nucleotide polymorphisms. Lower scores on cognitive measures were associated with increasing age, socioeconomic deprivation, blood pressure, waist-hip ratio, smoking, and vascular comorbidity (all p < 0.001). In a post hoc sensitivity analysis restricted to those aged over 50 years, there was still no signal of association. Our data add to our understanding of determinants of cognition but are not definitive; the variation in blood levels explained by SNPs was modest and our sample size may have been insufficient to detect a modest association.

    Original languageEnglish
    Article number80
    Number of pages9
    JournalAge
    Volume37
    Issue number4
    DOIs
    Publication statusPublished - 3 Aug 2015

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    Keywords

    • Cognition disorders
    • Dementia
    • Genomics
    • Haemostasis
    • Mendelian randomization analysis

    Cite this

    Quinn, T. J., Alghamdi, J., Padmanabhan, S., Porteous, D. J., Smith, B. H., Hocking, L., Deary, I. J., Gallacher, J., Messow, M., & Stott, D. J. (2015). Association between cognition and gene polymorphisms involved in thrombosis and haemostasis. Age, 37(4), [80]. https://doi.org/10.1007/s11357-015-9820-y