Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension

Maryam Barma; Faisel Khan; Rosemary J. G. Price; Peter T. Donnan; C. Martina Messow; Ian Ford; Alex McConnachie; Allan D. Struthers; Marion E. T. McMurdo; Miles D. Witham

doi:10.1007/s40520-016-0636-0

Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension

Maryam Barma (Lead / Corresponding author), Faisel Khan, Rosemary J. G. Price, Peter T. Donnan, C. Martina Messow, Ian Ford, Alex McConnachie, Allan D. Struthers, Marion E. T. McMurdo, Miles D. Witham

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Abstract

Background: Growth Differentiation Factor-15 (GDF-15) may be a biomarker of disease, protective response and/or prognosis, in older people with hypertension.
Aims: To correlate baseline GDF-15 levels with physical and vascular health data in this population.

Methods: Baseline blood samples were analysed using a GDF-15 ELISA assay kit. Correlations with baseline and 12-month outcome data, including measures of physical and vascular function, were performed.

Results: 147 individuals, mean age 76.8±4.7 years, were included. 77(52%) were male. Baseline logGDF15 showed significant correlations with age (r=0.37, p<0.001), total cholesterol (r=-0.33, p<0.001) and six-minute walking distance (r=-0.37, p<0.001). Age remained significantly associated with logGDF15 in multivariable analysis (beta=-0.29, p=0.001). Baseline logGDF15 was significantly associated with decline in sixminute walk distance over 12 months (beta=-0.27, p=0.01) in multivariable models. No significant correlations were seen with changes in vascular function over 12 months.

Conclusion: Baseline GDF-15 predicts declining physical, but not vascular, function in our population.

Original language	English
Pages (from-to)	1055-1059
Number of pages	5
Journal	Aging Clinical and Experimental Research
Volume	29
Issue number	5
Early online date	12 Oct 2016
DOIs	https://doi.org/10.1007/s40520-016-0636-0
Publication status	Published - 2016

Keywords

Ageing
Biomarker
Cardiovascular disease
Frailty
Inflammation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s40520-016-0636-0Licence: CC BY

Final Published Version
©The Author(s) 2016. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Final published version, 384 KBLicence: CC BY

Vitamin K Supplementation to Reduce Falls in Older People - A Pilot Multicentre Trial (Joint with University of Aberdeen and NHS Fife)
Donnan, P. (Investigator), McMurdo, M. (Investigator) & Witham, M. (Investigator)
1/01/16 → 31/08/18
Project: Research

Cite this

Barma, M., Khan, F., Price, R. J. G., Donnan, P. T., Messow, C. M., Ford, I., McConnachie, A., Struthers, A. D., McMurdo, M. E. T., & Witham, M. D. (2016). Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension. Aging Clinical and Experimental Research, 29(5), 1055-1059. https://doi.org/10.1007/s40520-016-0636-0

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abstract = "Background: Growth Differentiation Factor-15 (GDF-15) may be a biomarker of disease, protective response and/or prognosis, in older people with hypertension.Aims: To correlate baseline GDF-15 levels with physical and vascular health data in this population.Methods: Baseline blood samples were analysed using a GDF-15 ELISA assay kit. Correlations with baseline and 12-month outcome data, including measures of physical and vascular function, were performed.Results: 147 individuals, mean age 76.8±4.7 years, were included. 77(52%) were male. Baseline logGDF15 showed significant correlations with age (r=0.37, p<0.001), total cholesterol (r=-0.33, p<0.001) and six-minute walking distance (r=-0.37, p<0.001). Age remained significantly associated with logGDF15 in multivariable analysis (beta=-0.29, p=0.001). Baseline logGDF15 was significantly associated with decline in sixminute walk distance over 12 months (beta=-0.27, p=0.01) in multivariable models. No significant correlations were seen with changes in vascular function over 12 months.Conclusion: Baseline GDF-15 predicts declining physical, but not vascular, function in our population.",

keywords = "Ageing, Biomarker, Cardiovascular disease, Frailty, Inflammation",

author = "Maryam Barma and Faisel Khan and Price, {Rosemary J. G.} and Donnan, {Peter T.} and Messow, {C. Martina} and Ian Ford and Alex McConnachie and Struthers, {Allan D.} and McMurdo, {Marion E. T.} and Witham, {Miles D.}",

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doi = "10.1007/s40520-016-0636-0",

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pages = "1055--1059",

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T1 - Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension

AU - Barma, Maryam

AU - Khan, Faisel

AU - Price, Rosemary J. G.

AU - Donnan, Peter T.

AU - Messow, C. Martina

AU - Ford, Ian

AU - McConnachie, Alex

AU - Struthers, Allan D.

AU - McMurdo, Marion E. T.

AU - Witham, Miles D.

N1 - The VitDISH trial was funded by Chief Scientist Office, Scottish Government (grant number CZH/4/1100)

PY - 2016

Y1 - 2016

N2 - Background: Growth Differentiation Factor-15 (GDF-15) may be a biomarker of disease, protective response and/or prognosis, in older people with hypertension.Aims: To correlate baseline GDF-15 levels with physical and vascular health data in this population.Methods: Baseline blood samples were analysed using a GDF-15 ELISA assay kit. Correlations with baseline and 12-month outcome data, including measures of physical and vascular function, were performed.Results: 147 individuals, mean age 76.8±4.7 years, were included. 77(52%) were male. Baseline logGDF15 showed significant correlations with age (r=0.37, p<0.001), total cholesterol (r=-0.33, p<0.001) and six-minute walking distance (r=-0.37, p<0.001). Age remained significantly associated with logGDF15 in multivariable analysis (beta=-0.29, p=0.001). Baseline logGDF15 was significantly associated with decline in sixminute walk distance over 12 months (beta=-0.27, p=0.01) in multivariable models. No significant correlations were seen with changes in vascular function over 12 months.Conclusion: Baseline GDF-15 predicts declining physical, but not vascular, function in our population.

AB - Background: Growth Differentiation Factor-15 (GDF-15) may be a biomarker of disease, protective response and/or prognosis, in older people with hypertension.Aims: To correlate baseline GDF-15 levels with physical and vascular health data in this population.Methods: Baseline blood samples were analysed using a GDF-15 ELISA assay kit. Correlations with baseline and 12-month outcome data, including measures of physical and vascular function, were performed.Results: 147 individuals, mean age 76.8±4.7 years, were included. 77(52%) were male. Baseline logGDF15 showed significant correlations with age (r=0.37, p<0.001), total cholesterol (r=-0.33, p<0.001) and six-minute walking distance (r=-0.37, p<0.001). Age remained significantly associated with logGDF15 in multivariable analysis (beta=-0.29, p=0.001). Baseline logGDF15 was significantly associated with decline in sixminute walk distance over 12 months (beta=-0.27, p=0.01) in multivariable models. No significant correlations were seen with changes in vascular function over 12 months.Conclusion: Baseline GDF-15 predicts declining physical, but not vascular, function in our population.

KW - Ageing

KW - Biomarker

KW - Cardiovascular disease

KW - Frailty

KW - Inflammation

U2 - 10.1007/s40520-016-0636-0

DO - 10.1007/s40520-016-0636-0

M3 - Article

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SN - 1594-0667

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JO - Aging Clinical and Experimental Research

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ER -

Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension

Abstract

Keywords

UN SDGs

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Projects

Vitamin K Supplementation to Reduce Falls in Older People - A Pilot Multicentre Trial (Joint with University of Aberdeen and NHS Fife)

Cite this