Aims: To correlate baseline GDF-15 levels with physical and vascular health data in this population.
Methods: Baseline blood samples were analysed using a GDF-15 ELISA assay kit. Correlations with baseline and 12-month outcome data, including measures of physical and vascular function, were performed.
Results: 147 individuals, mean age 76.8±4.7 years, were included. 77(52%) were male. Baseline logGDF15 showed significant correlations with age (r=0.37, p<0.001), total cholesterol (r=-0.33, p<0.001) and six-minute walking distance (r=-0.37, p<0.001). Age remained significantly associated with logGDF15 in multivariable analysis (beta=-0.29, p=0.001). Baseline logGDF15 was significantly associated with decline in sixminute walk distance over 12 months (beta=-0.27, p=0.01) in multivariable models. No significant correlations were seen with changes in vascular function over 12 months.
Conclusion: Baseline GDF-15 predicts declining physical, but not vascular, function in our population.
- Cardiovascular disease