Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension

Maryam Barma (Lead / Corresponding author), Faisel Khan, Rosemary J. G. Price, Peter T. Donnan, C. Martina Messow, Ian Ford, Alex McConnachie, Allan D. Struthers, Marion E. T. McMurdo, Miles D. Witham

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Abstract

Background: Growth Differentiation Factor-15 (GDF-15) may be a biomarker of disease, protective response and/or prognosis, in older people with hypertension.
Aims: To correlate baseline GDF-15 levels with physical and vascular health data in this population.

Methods: Baseline blood samples were analysed using a GDF-15 ELISA assay kit. Correlations with baseline and 12-month outcome data, including measures of physical and vascular function, were performed.

Results: 147 individuals, mean age 76.8±4.7 years, were included. 77(52%) were male. Baseline logGDF15 showed significant correlations with age (r=0.37, p<0.001), total cholesterol (r=-0.33, p<0.001) and six-minute walking distance (r=-0.37, p<0.001). Age remained significantly associated with logGDF15 in multivariable analysis (beta=-0.29, p=0.001). Baseline logGDF15 was significantly associated with decline in sixminute walk distance over 12 months (beta=-0.27, p=0.01) in multivariable models. No significant correlations were seen with changes in vascular function over 12 months.

Conclusion: Baseline GDF-15 predicts declining physical, but not vascular, function in our population.
Original languageEnglish
Pages (from-to)1055-1059
Number of pages5
JournalAging Clinical and Experimental Research
Volume29
Issue number5
Early online date12 Oct 2016
DOIs
Publication statusPublished - 2016

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Growth Differentiation Factor 15
Blood Vessels
Hypertension
Population
Walking
Biomarkers
Enzyme-Linked Immunosorbent Assay
Cholesterol
Health

Keywords

  • Ageing
  • Biomarker
  • Cardiovascular disease
  • Frailty
  • Inflammation

Cite this

@article{e101fdd4fb5d4115bb113ba1cc09e972,
title = "Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension",
abstract = "Background: Growth Differentiation Factor-15 (GDF-15) may be a biomarker of disease, protective response and/or prognosis, in older people with hypertension.Aims: To correlate baseline GDF-15 levels with physical and vascular health data in this population.Methods: Baseline blood samples were analysed using a GDF-15 ELISA assay kit. Correlations with baseline and 12-month outcome data, including measures of physical and vascular function, were performed.Results: 147 individuals, mean age 76.8±4.7 years, were included. 77(52{\%}) were male. Baseline logGDF15 showed significant correlations with age (r=0.37, p<0.001), total cholesterol (r=-0.33, p<0.001) and six-minute walking distance (r=-0.37, p<0.001). Age remained significantly associated with logGDF15 in multivariable analysis (beta=-0.29, p=0.001). Baseline logGDF15 was significantly associated with decline in sixminute walk distance over 12 months (beta=-0.27, p=0.01) in multivariable models. No significant correlations were seen with changes in vascular function over 12 months.Conclusion: Baseline GDF-15 predicts declining physical, but not vascular, function in our population.",
keywords = "Ageing, Biomarker, Cardiovascular disease, Frailty, Inflammation",
author = "Maryam Barma and Faisel Khan and Price, {Rosemary J. G.} and Donnan, {Peter T.} and Messow, {C. Martina} and Ian Ford and Alex McConnachie and Struthers, {Allan D.} and McMurdo, {Marion E. T.} and Witham, {Miles D.}",
note = "The VitDISH trial was funded by Chief Scientist Office, Scottish Government (grant number CZH/4/1100)",
year = "2016",
doi = "10.1007/s40520-016-0636-0",
language = "English",
volume = "29",
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Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension. / Barma, Maryam (Lead / Corresponding author); Khan, Faisel; Price, Rosemary J. G.; Donnan, Peter T.; Messow, C. Martina; Ford, Ian; McConnachie, Alex; Struthers, Allan D.; McMurdo, Marion E. T.; Witham, Miles D.

In: Aging Clinical and Experimental Research, Vol. 29, No. 5, 2016, p. 1055-1059.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension

AU - Barma, Maryam

AU - Khan, Faisel

AU - Price, Rosemary J. G.

AU - Donnan, Peter T.

AU - Messow, C. Martina

AU - Ford, Ian

AU - McConnachie, Alex

AU - Struthers, Allan D.

AU - McMurdo, Marion E. T.

AU - Witham, Miles D.

N1 - The VitDISH trial was funded by Chief Scientist Office, Scottish Government (grant number CZH/4/1100)

PY - 2016

Y1 - 2016

N2 - Background: Growth Differentiation Factor-15 (GDF-15) may be a biomarker of disease, protective response and/or prognosis, in older people with hypertension.Aims: To correlate baseline GDF-15 levels with physical and vascular health data in this population.Methods: Baseline blood samples were analysed using a GDF-15 ELISA assay kit. Correlations with baseline and 12-month outcome data, including measures of physical and vascular function, were performed.Results: 147 individuals, mean age 76.8±4.7 years, were included. 77(52%) were male. Baseline logGDF15 showed significant correlations with age (r=0.37, p<0.001), total cholesterol (r=-0.33, p<0.001) and six-minute walking distance (r=-0.37, p<0.001). Age remained significantly associated with logGDF15 in multivariable analysis (beta=-0.29, p=0.001). Baseline logGDF15 was significantly associated with decline in sixminute walk distance over 12 months (beta=-0.27, p=0.01) in multivariable models. No significant correlations were seen with changes in vascular function over 12 months.Conclusion: Baseline GDF-15 predicts declining physical, but not vascular, function in our population.

AB - Background: Growth Differentiation Factor-15 (GDF-15) may be a biomarker of disease, protective response and/or prognosis, in older people with hypertension.Aims: To correlate baseline GDF-15 levels with physical and vascular health data in this population.Methods: Baseline blood samples were analysed using a GDF-15 ELISA assay kit. Correlations with baseline and 12-month outcome data, including measures of physical and vascular function, were performed.Results: 147 individuals, mean age 76.8±4.7 years, were included. 77(52%) were male. Baseline logGDF15 showed significant correlations with age (r=0.37, p<0.001), total cholesterol (r=-0.33, p<0.001) and six-minute walking distance (r=-0.37, p<0.001). Age remained significantly associated with logGDF15 in multivariable analysis (beta=-0.29, p=0.001). Baseline logGDF15 was significantly associated with decline in sixminute walk distance over 12 months (beta=-0.27, p=0.01) in multivariable models. No significant correlations were seen with changes in vascular function over 12 months.Conclusion: Baseline GDF-15 predicts declining physical, but not vascular, function in our population.

KW - Ageing

KW - Biomarker

KW - Cardiovascular disease

KW - Frailty

KW - Inflammation

U2 - 10.1007/s40520-016-0636-0

DO - 10.1007/s40520-016-0636-0

M3 - Article

C2 - 27734214

VL - 29

SP - 1055

EP - 1059

JO - Aging Clinical and Experimental Research

JF - Aging Clinical and Experimental Research

SN - 1594-0667

IS - 5

ER -