Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension

Maryam Barma (Lead / Corresponding author), Faisel Khan, Rosemary J. G. Price, Peter T. Donnan, C. Martina Messow, Ian Ford, Alex McConnachie, Allan D. Struthers, Marion E. T. McMurdo, Miles D. Witham

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Abstract

Background: Growth Differentiation Factor-15 (GDF-15) may be a biomarker of disease, protective response and/or prognosis, in older people with hypertension.
Aims: To correlate baseline GDF-15 levels with physical and vascular health data in this population.

Methods: Baseline blood samples were analysed using a GDF-15 ELISA assay kit. Correlations with baseline and 12-month outcome data, including measures of physical and vascular function, were performed.

Results: 147 individuals, mean age 76.8±4.7 years, were included. 77(52%) were male. Baseline logGDF15 showed significant correlations with age (r=0.37, p<0.001), total cholesterol (r=-0.33, p<0.001) and six-minute walking distance (r=-0.37, p<0.001). Age remained significantly associated with logGDF15 in multivariable analysis (beta=-0.29, p=0.001). Baseline logGDF15 was significantly associated with decline in sixminute walk distance over 12 months (beta=-0.27, p=0.01) in multivariable models. No significant correlations were seen with changes in vascular function over 12 months.

Conclusion: Baseline GDF-15 predicts declining physical, but not vascular, function in our population.
Original languageEnglish
Pages (from-to)1055-1059
Number of pages5
JournalAging Clinical and Experimental Research
Volume29
Issue number5
Early online date12 Oct 2016
DOIs
Publication statusPublished - 2016

Keywords

  • Ageing
  • Biomarker
  • Cardiovascular disease
  • Frailty
  • Inflammation

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