Association between retinal vasculature and muscle mass in older people

Deepa Sumukadas (Lead / Corresponding author), Marion McMurdo, Ilaria Pieretti, Lucia Ballerini, Rosemary Price, Peter Wilson, Alex Doney, Graham Leese, Emanuele Trucco

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Sarcopenia in older people is a major health issue and its early detection could help target interventions and improve health. Evidence suggests that poor muscle mass is associated with greater arterial stiffness and cardiovascular risk. Arterial stiffness in turn is associated with smaller retinal artery width. This study examined the association of muscle mass in older people with retinal vascular width, a non-invasive measure of vascular function.

Methods: Participants >65 years were recruited to a cross-sectional study.

Exclusions: Inability to walk independently; diabetes mellitus; stroke (within 6 months), severe macular degeneration, glaucoma, retinal dystrophy; advanced cataract. Digital Retinal images of both eyes were analysed using the VAMPIRE software suite. Central Retinal Artery and Vein Equivalents (CRVE and CRAE) were measured. Body composition was measured using Dual Energy X ray Absorptimetry (DXA). Appendicular Skeletal Muscle Mass/Height(2) was calculated. Physical function was measured: 6-min walk distance, Short Physical performance battery, handgrip strength and quadriceps strength.

Results: 79 participants with mean age 72 (SD 6) years were recruited. 44% were female. Digital Retinal images of sufficient quality for measuring CRAE and CRVE were available for 51/75 (68%) of participants. Regression analysis showed significant association between larger ASMM/H(2) and smaller CRAE (β=-0.20, p=0.001) and CRVE (β=-0.12, p=0.05). Handgrip strength, body mass index and sex combined with CRAE explained 88% and with CRVE explained 86% of the variance in ASMM/H2.

Conclusion: Larger muscle mass was significantly associated with smaller retinal artery size in older people. This unexpected finding needs further investigation.

Original languageEnglish
Pages (from-to)425-428
Number of pages4
JournalArchives of Gerontology and Geriatrics
Volume61
Issue number3
Early online date4 Aug 2015
DOIs
Publication statusPublished - Nov 2015

Fingerprint

Retinal Artery
Vascular Stiffness
Muscles
Retinal Dystrophies
Sarcopenia
Retinal Vein
Retinal Vessels
Health
Macular Degeneration
stroke
Body Composition
health
cross-sectional study
Glaucoma
Cataract
chronic illness
Blood Vessels
Diabetes Mellitus
regression analysis
Skeletal Muscle

Cite this

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title = "Association between retinal vasculature and muscle mass in older people",
abstract = "Sarcopenia in older people is a major health issue and its early detection could help target interventions and improve health. Evidence suggests that poor muscle mass is associated with greater arterial stiffness and cardiovascular risk. Arterial stiffness in turn is associated with smaller retinal artery width. This study examined the association of muscle mass in older people with retinal vascular width, a non-invasive measure of vascular function.Methods: Participants >65 years were recruited to a cross-sectional study.Exclusions: Inability to walk independently; diabetes mellitus; stroke (within 6 months), severe macular degeneration, glaucoma, retinal dystrophy; advanced cataract. Digital Retinal images of both eyes were analysed using the VAMPIRE software suite. Central Retinal Artery and Vein Equivalents (CRVE and CRAE) were measured. Body composition was measured using Dual Energy X ray Absorptimetry (DXA). Appendicular Skeletal Muscle Mass/Height(2) was calculated. Physical function was measured: 6-min walk distance, Short Physical performance battery, handgrip strength and quadriceps strength.Results: 79 participants with mean age 72 (SD 6) years were recruited. 44{\%} were female. Digital Retinal images of sufficient quality for measuring CRAE and CRVE were available for 51/75 (68{\%}) of participants. Regression analysis showed significant association between larger ASMM/H(2) and smaller CRAE (β=-0.20, p=0.001) and CRVE (β=-0.12, p=0.05). Handgrip strength, body mass index and sex combined with CRAE explained 88{\%} and with CRVE explained 86{\%} of the variance in ASMM/H2.Conclusion: Larger muscle mass was significantly associated with smaller retinal artery size in older people. This unexpected finding needs further investigation.",
author = "Deepa Sumukadas and Marion McMurdo and Ilaria Pieretti and Lucia Ballerini and Rosemary Price and Peter Wilson and Alex Doney and Graham Leese and Emanuele Trucco",
note = "Copyright {\circledC} 2015 Elsevier Ireland Ltd. All rights reserved.",
year = "2015",
month = "11",
doi = "10.1016/j.archger.2015.08.006",
language = "English",
volume = "61",
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TY - JOUR

T1 - Association between retinal vasculature and muscle mass in older people

AU - Sumukadas, Deepa

AU - McMurdo, Marion

AU - Pieretti, Ilaria

AU - Ballerini, Lucia

AU - Price, Rosemary

AU - Wilson, Peter

AU - Doney, Alex

AU - Leese, Graham

AU - Trucco, Emanuele

N1 - Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

PY - 2015/11

Y1 - 2015/11

N2 - Sarcopenia in older people is a major health issue and its early detection could help target interventions and improve health. Evidence suggests that poor muscle mass is associated with greater arterial stiffness and cardiovascular risk. Arterial stiffness in turn is associated with smaller retinal artery width. This study examined the association of muscle mass in older people with retinal vascular width, a non-invasive measure of vascular function.Methods: Participants >65 years were recruited to a cross-sectional study.Exclusions: Inability to walk independently; diabetes mellitus; stroke (within 6 months), severe macular degeneration, glaucoma, retinal dystrophy; advanced cataract. Digital Retinal images of both eyes were analysed using the VAMPIRE software suite. Central Retinal Artery and Vein Equivalents (CRVE and CRAE) were measured. Body composition was measured using Dual Energy X ray Absorptimetry (DXA). Appendicular Skeletal Muscle Mass/Height(2) was calculated. Physical function was measured: 6-min walk distance, Short Physical performance battery, handgrip strength and quadriceps strength.Results: 79 participants with mean age 72 (SD 6) years were recruited. 44% were female. Digital Retinal images of sufficient quality for measuring CRAE and CRVE were available for 51/75 (68%) of participants. Regression analysis showed significant association between larger ASMM/H(2) and smaller CRAE (β=-0.20, p=0.001) and CRVE (β=-0.12, p=0.05). Handgrip strength, body mass index and sex combined with CRAE explained 88% and with CRVE explained 86% of the variance in ASMM/H2.Conclusion: Larger muscle mass was significantly associated with smaller retinal artery size in older people. This unexpected finding needs further investigation.

AB - Sarcopenia in older people is a major health issue and its early detection could help target interventions and improve health. Evidence suggests that poor muscle mass is associated with greater arterial stiffness and cardiovascular risk. Arterial stiffness in turn is associated with smaller retinal artery width. This study examined the association of muscle mass in older people with retinal vascular width, a non-invasive measure of vascular function.Methods: Participants >65 years were recruited to a cross-sectional study.Exclusions: Inability to walk independently; diabetes mellitus; stroke (within 6 months), severe macular degeneration, glaucoma, retinal dystrophy; advanced cataract. Digital Retinal images of both eyes were analysed using the VAMPIRE software suite. Central Retinal Artery and Vein Equivalents (CRVE and CRAE) were measured. Body composition was measured using Dual Energy X ray Absorptimetry (DXA). Appendicular Skeletal Muscle Mass/Height(2) was calculated. Physical function was measured: 6-min walk distance, Short Physical performance battery, handgrip strength and quadriceps strength.Results: 79 participants with mean age 72 (SD 6) years were recruited. 44% were female. Digital Retinal images of sufficient quality for measuring CRAE and CRVE were available for 51/75 (68%) of participants. Regression analysis showed significant association between larger ASMM/H(2) and smaller CRAE (β=-0.20, p=0.001) and CRVE (β=-0.12, p=0.05). Handgrip strength, body mass index and sex combined with CRAE explained 88% and with CRVE explained 86% of the variance in ASMM/H2.Conclusion: Larger muscle mass was significantly associated with smaller retinal artery size in older people. This unexpected finding needs further investigation.

U2 - 10.1016/j.archger.2015.08.006

DO - 10.1016/j.archger.2015.08.006

M3 - Article

C2 - 26276247

VL - 61

SP - 425

EP - 428

JO - Archives of Gerontology and Geriatrics

JF - Archives of Gerontology and Geriatrics

SN - 0167-4943

IS - 3

ER -