TY - JOUR
T1 - Association of high-risk coronary atherosclerosis at CCTA with clinical and circulating biomarkers
T2 - Insight from CAPIRE study
AU - Conte, Edoardo
AU - Andreini, Daniele
AU - Magnoni, Marco
AU - Masson, Serge
AU - Mushtaq, Saima
AU - Berti, Sergio
AU - Canestrari, Mauro
AU - Casolo, Giancarlo
AU - Gabrielli, Domenico
AU - Latini, R.
AU - Marraccini, Paolo
AU - Moccetti, Tiziano
AU - Modena, Maria Grazia
AU - Pontone, Gianluca
AU - Gorini, Marco
AU - Maggioni, Aldo P.
AU - Maseri, Attilio
AU - Gaspari, F.
AU - Ferrari, S.
AU - Cannata, A.
AU - Stucchi, N.
AU - Fois, M.
AU - Bernasconi, R.
AU - Balconi, G.
AU - Vago, T.
AU - Letizia, T.
AU - Bottazzi, B.
AU - Leone, R.
AU - Suliman, I.
AU - Sommaruga, M.
AU - Gremigni, P.
AU - Olivieri, R.
AU - Pennacchietti, L.
AU - Magnacca, M.
AU - Rossi, M. G.
AU - Pasotti, E.
AU - Clemente, A.
AU - Mushtaq, S.
AU - Mauro, E.
AU - Pigazzani, F.
N1 - Funding Information:
Daniele Andreini declares the following conflict of interest: speaker bureau for GE Healthcare, research grant (to the Institution) from GE Healthcare and Bracco. The other authors have nothing to declare. Gianluca Pontone declares the following conflict of interest: Institutional fee as speaker and/or research grant from GE Helthcare, Bracco, Bayer, Medtronic, Heartflow.
Funding Information:
The study is promoted by GISSI Group (ANMCO, Mario Negri Institute and Heart Care Foundation Onlus). The sponsor of the study is the Heart Care Foundation Onlus, an independent non-profit institution. The study is partially supported by an unrestricted grant by Ferrero Spa and from the contributions collected by the Heart Care Foundation Onlus, in the years 2009 and 2010, from the fundraising campaigns “Accendi il tuo cuore".
Publisher Copyright:
© 2020 Society of Cardiovascular Computed Tomography
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Background: High-risk coronary atherosclerosis features evaluated coronary CT angiography (CCTA) were suggested to have a prognostic role. The present study aimed to evaluate the association of circulating biomarkers with high-risk plaque features assessed by CCTA. Methods: A consecutive cohort of subjects who underwent CCTA because of suspected CAD was screened for inclusion in the CAPIRE study. Based on risk factors (RF) burden patients were defined as having a low clinical risk (0–1 RF with the exclusion of patients with diabetes mellitus as single RF) or an high clinical risk (≥3 RFs). In all patients, measurement of inflammatory biomarkers and CCTA analysis focused on high-risk plaque features were performed. Univariate and multivariate logistic regression analysis were used to evaluate the relationship between clinical and biological variables with CCTA advanced plaque features. Results: 528 patients were enrolled in CAPIRE study. Older age and male sex appeared to be predictors of qualitative high-risk plaque features and associated with the presence of elevated total, non-calcified and low-attenuation plaque volume. Among circulating biomarkers only hs-CRP was found to be associated with qualitative high-risk plaque features (OR 2.02, p = 0.004 and 2.02, p = 0.012 for LAP and RI > 1.1, respectively) with borderline association with LAP-Vol (OR 1.52, p = 0.076); HbA1c and PTX-3 resulted to be significantly associated with quantitative high-risk plaque features (OR 1.71, p = 0.003 and 1.04, p = 0.002 for LAP-Vol, respectively). Conclusions: Our results support the association between inflammatory biomarkers (hs-CRP, PTX- 3), HbA1c and high-risk atherosclerotic features detected by CCTA. Male sex and older age are significant predictors of high-risk atherosclerosis.
AB - Background: High-risk coronary atherosclerosis features evaluated coronary CT angiography (CCTA) were suggested to have a prognostic role. The present study aimed to evaluate the association of circulating biomarkers with high-risk plaque features assessed by CCTA. Methods: A consecutive cohort of subjects who underwent CCTA because of suspected CAD was screened for inclusion in the CAPIRE study. Based on risk factors (RF) burden patients were defined as having a low clinical risk (0–1 RF with the exclusion of patients with diabetes mellitus as single RF) or an high clinical risk (≥3 RFs). In all patients, measurement of inflammatory biomarkers and CCTA analysis focused on high-risk plaque features were performed. Univariate and multivariate logistic regression analysis were used to evaluate the relationship between clinical and biological variables with CCTA advanced plaque features. Results: 528 patients were enrolled in CAPIRE study. Older age and male sex appeared to be predictors of qualitative high-risk plaque features and associated with the presence of elevated total, non-calcified and low-attenuation plaque volume. Among circulating biomarkers only hs-CRP was found to be associated with qualitative high-risk plaque features (OR 2.02, p = 0.004 and 2.02, p = 0.012 for LAP and RI > 1.1, respectively) with borderline association with LAP-Vol (OR 1.52, p = 0.076); HbA1c and PTX-3 resulted to be significantly associated with quantitative high-risk plaque features (OR 1.71, p = 0.003 and 1.04, p = 0.002 for LAP-Vol, respectively). Conclusions: Our results support the association between inflammatory biomarkers (hs-CRP, PTX- 3), HbA1c and high-risk atherosclerotic features detected by CCTA. Male sex and older age are significant predictors of high-risk atherosclerosis.
KW - Cardiac computed tomography
KW - Cardiovascular prevention
KW - Coronary atherosclerosis
KW - Coronary plaque
KW - High-risk plaque features
KW - Inflammation
UR - http://www.scopus.com/inward/record.url?scp=85086508540&partnerID=8YFLogxK
U2 - 10.1016/j.jcct.2020.03.005
DO - 10.1016/j.jcct.2020.03.005
M3 - Article
C2 - 32563713
AN - SCOPUS:85086508540
SN - 1934-5925
VL - 15
SP - 73
EP - 80
JO - Journal of Cardiovascular Computed Tomography
JF - Journal of Cardiovascular Computed Tomography
IS - 1
ER -
