Association of high-risk coronary atherosclerosis at CCTA with clinical and circulating biomarkers: Insight from CAPIRE study

, , , , , , Edoardo Conte, Daniele Andreini, Marco Magnoni, Serge Masson, Saima Mushtaq, Sergio Berti, Mauro Canestrari, Giancarlo Casolo, Domenico Gabrielli, R. Latini, Paolo Marraccini, Tiziano Moccetti, Maria Grazia Modena, Gianluca PontoneMarco Gorini, Aldo P. Maggioni, Attilio Maseri, T. Moccetti, F. Gaspari, F. Pigazzani

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15 Citations (Scopus)


Background: High-risk coronary atherosclerosis features evaluated coronary CT angiography (CCTA) were suggested to have a prognostic role. The present study aimed to evaluate the association of circulating biomarkers with high-risk plaque features assessed by CCTA. Methods: A consecutive cohort of subjects who underwent CCTA because of suspected CAD was screened for inclusion in the CAPIRE study. Based on risk factors (RF) burden patients were defined as having a low clinical risk (0–1 RF with the exclusion of patients with diabetes mellitus as single RF) or an high clinical risk (≥3 RFs). In all patients, measurement of inflammatory biomarkers and CCTA analysis focused on high-risk plaque features were performed. Univariate and multivariate logistic regression analysis were used to evaluate the relationship between clinical and biological variables with CCTA advanced plaque features. Results: 528 patients were enrolled in CAPIRE study. Older age and male sex appeared to be predictors of qualitative high-risk plaque features and associated with the presence of elevated total, non-calcified and low-attenuation plaque volume. Among circulating biomarkers only hs-CRP was found to be associated with qualitative high-risk plaque features (OR 2.02, p = 0.004 and 2.02, p = 0.012 for LAP and RI > 1.1, respectively) with borderline association with LAP-Vol (OR 1.52, p = 0.076); HbA1c and PTX-3 resulted to be significantly associated with quantitative high-risk plaque features (OR 1.71, p = 0.003 and 1.04, p = 0.002 for LAP-Vol, respectively). Conclusions: Our results support the association between inflammatory biomarkers (hs-CRP, PTX- 3), HbA1c and high-risk atherosclerotic features detected by CCTA. Male sex and older age are significant predictors of high-risk atherosclerosis.

Original languageEnglish
Pages (from-to)73-80
Number of pages8
JournalJournal of Cardiovascular Computed Tomography
Issue number1
Early online date10 Jun 2020
Publication statusPublished - 1 Jan 2021


  • Cardiac computed tomography
  • Cardiovascular prevention
  • Coronary atherosclerosis
  • Coronary plaque
  • High-risk plaque features
  • Inflammation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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