Association of high-risk coronary atherosclerosis at CCTA with clinical and circulating biomarkers: Insight from CAPIRE study

Edoardo Conte; Daniele Andreini; Marco Magnoni; Serge Masson; Saima Mushtaq; Sergio Berti; Mauro Canestrari; Giancarlo Casolo; Domenico Gabrielli; R. Latini; Paolo Marraccini; Tiziano Moccetti; Maria Grazia Modena; Gianluca Pontone; Marco Gorini; Aldo P. Maggioni; Attilio Maseri; F. Gaspari; F. Pigazzani

doi:10.1016/j.jcct.2020.03.005

Association of high-risk coronary atherosclerosis at CCTA with clinical and circulating biomarkers: Insight from CAPIRE study

,
,
,
,
,
, Edoardo Conte
, Daniele Andreini
, Marco Magnoni
, Serge Masson
, Saima Mushtaq
, Sergio Berti
, Mauro Canestrari
, Giancarlo Casolo
, Domenico Gabrielli
, R. Latini
, Paolo Marraccini
, Tiziano Moccetti
, Maria Grazia Modena
, Gianluca Pontone

Marco Gorini, Aldo P. Maggioni, Attilio Maseri, F. Gaspari, F. Pigazzani

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Background: High-risk coronary atherosclerosis features evaluated coronary CT angiography (CCTA) were suggested to have a prognostic role. The present study aimed to evaluate the association of circulating biomarkers with high-risk plaque features assessed by CCTA. Methods: A consecutive cohort of subjects who underwent CCTA because of suspected CAD was screened for inclusion in the CAPIRE study. Based on risk factors (RF) burden patients were defined as having a low clinical risk (0–1 RF with the exclusion of patients with diabetes mellitus as single RF) or an high clinical risk (≥3 RFs). In all patients, measurement of inflammatory biomarkers and CCTA analysis focused on high-risk plaque features were performed. Univariate and multivariate logistic regression analysis were used to evaluate the relationship between clinical and biological variables with CCTA advanced plaque features. Results: 528 patients were enrolled in CAPIRE study. Older age and male sex appeared to be predictors of qualitative high-risk plaque features and associated with the presence of elevated total, non-calcified and low-attenuation plaque volume. Among circulating biomarkers only hs-CRP was found to be associated with qualitative high-risk plaque features (OR 2.02, p = 0.004 and 2.02, p = 0.012 for LAP and RI > 1.1, respectively) with borderline association with LAP-Vol (OR 1.52, p = 0.076); HbA1c and PTX-3 resulted to be significantly associated with quantitative high-risk plaque features (OR 1.71, p = 0.003 and 1.04, p = 0.002 for LAP-Vol, respectively). Conclusions: Our results support the association between inflammatory biomarkers (hs-CRP, PTX- 3), HbA1c and high-risk atherosclerotic features detected by CCTA. Male sex and older age are significant predictors of high-risk atherosclerosis.

Original language	English
Pages (from-to)	73-80
Number of pages	8
Journal	Journal of Cardiovascular Computed Tomography
Volume	15
Issue number	1
Early online date	10 Jun 2020
DOIs	https://doi.org/10.1016/j.jcct.2020.03.005
Publication status	Published - 1 Jan 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cardiac computed tomography
Cardiovascular prevention
Coronary atherosclerosis
Coronary plaque
High-risk plaque features
Inflammation

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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10.1016/j.jcct.2020.03.005

Cite this

, Conte, E., Andreini, D., Magnoni, M., Masson, S., Mushtaq, S., Berti, S., Canestrari, M., Casolo, G., Gabrielli, D., Latini, R., Marraccini, P., Moccetti, T., & Modena, M. G., ... Pigazzani, F. (2021). Association of high-risk coronary atherosclerosis at CCTA with clinical and circulating biomarkers: Insight from CAPIRE study. Journal of Cardiovascular Computed Tomography, 15(1), 73-80. https://doi.org/10.1016/j.jcct.2020.03.005

@article{26489f34a73242b1abd3cb7365dc7f17,

title = "Association of high-risk coronary atherosclerosis at CCTA with clinical and circulating biomarkers: Insight from CAPIRE study",

abstract = "Background: High-risk coronary atherosclerosis features evaluated coronary CT angiography (CCTA) were suggested to have a prognostic role. The present study aimed to evaluate the association of circulating biomarkers with high-risk plaque features assessed by CCTA. Methods: A consecutive cohort of subjects who underwent CCTA because of suspected CAD was screened for inclusion in the CAPIRE study. Based on risk factors (RF) burden patients were defined as having a low clinical risk (0{\textendash}1 RF with the exclusion of patients with diabetes mellitus as single RF) or an high clinical risk (≥3 RFs). In all patients, measurement of inflammatory biomarkers and CCTA analysis focused on high-risk plaque features were performed. Univariate and multivariate logistic regression analysis were used to evaluate the relationship between clinical and biological variables with CCTA advanced plaque features. Results: 528 patients were enrolled in CAPIRE study. Older age and male sex appeared to be predictors of qualitative high-risk plaque features and associated with the presence of elevated total, non-calcified and low-attenuation plaque volume. Among circulating biomarkers only hs-CRP was found to be associated with qualitative high-risk plaque features (OR 2.02, p = 0.004 and 2.02, p = 0.012 for LAP and RI > 1.1, respectively) with borderline association with LAP-Vol (OR 1.52, p = 0.076); HbA1c and PTX-3 resulted to be significantly associated with quantitative high-risk plaque features (OR 1.71, p = 0.003 and 1.04, p = 0.002 for LAP-Vol, respectively). Conclusions: Our results support the association between inflammatory biomarkers (hs-CRP, PTX- 3), HbA1c and high-risk atherosclerotic features detected by CCTA. Male sex and older age are significant predictors of high-risk atherosclerosis.",

keywords = "Cardiac computed tomography, Cardiovascular prevention, Coronary atherosclerosis, Coronary plaque, High-risk plaque features, Inflammation",

author = "Edoardo Conte and Daniele Andreini and Marco Magnoni and Serge Masson and Saima Mushtaq and Sergio Berti and Mauro Canestrari and Giancarlo Casolo and Domenico Gabrielli and R. Latini and Paolo Marraccini and Tiziano Moccetti and Modena, \{Maria Grazia\} and Gianluca Pontone and Marco Gorini and Maggioni, \{Aldo P.\} and Attilio Maseri and F. Gaspari and S. Ferrari and A. Cannata and N. Stucchi and M. Fois and R. Bernasconi and G. Balconi and T. Vago and T. Letizia and B. Bottazzi and R. Leone and I. Suliman and M. Sommaruga and P. Gremigni and R. Olivieri and L. Pennacchietti and M. Magnacca and Rossi, \{M. G.\} and E. Pasotti and A. Clemente and S. Mushtaq and E. Mauro and F. Pigazzani",

note = "Funding Information: Daniele Andreini declares the following conflict of interest: speaker bureau for GE Healthcare, research grant (to the Institution) from GE Healthcare and Bracco. The other authors have nothing to declare. Gianluca Pontone declares the following conflict of interest: Institutional fee as speaker and/or research grant from GE Helthcare, Bracco, Bayer, Medtronic, Heartflow. Funding Information: The study is promoted by GISSI Group (ANMCO, Mario Negri Institute and Heart Care Foundation Onlus). The sponsor of the study is the Heart Care Foundation Onlus, an independent non-profit institution. The study is partially supported by an unrestricted grant by Ferrero Spa and from the contributions collected by the Heart Care Foundation Onlus, in the years 2009 and 2010, from the fundraising campaigns {\textquotedblleft}Accendi il tuo cuore{"}. Publisher Copyright: {\textcopyright} 2020 Society of Cardiovascular Computed Tomography",

year = "2021",

month = jan,

day = "1",

doi = "10.1016/j.jcct.2020.03.005",

language = "English",

volume = "15",

pages = "73--80",

journal = "Journal of Cardiovascular Computed Tomography",

issn = "1934-5925",

publisher = "Elsevier",

number = "1",

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Conte, E, Andreini, D, Magnoni, M, Masson, S, Mushtaq, S, Berti, S, Canestrari, M, Casolo, G, Gabrielli, D, Latini, R, Marraccini, P, Moccetti, T & Modena, MG & Pontone, G & Gorini, M & Maggioni, AP & Maseri, A & Gaspari, F & Pigazzani, F 2021, 'Association of high-risk coronary atherosclerosis at CCTA with clinical and circulating biomarkers: Insight from CAPIRE study', Journal of Cardiovascular Computed Tomography, vol. 15, no. 1, pp. 73-80. https://doi.org/10.1016/j.jcct.2020.03.005

TY - JOUR

T1 - Association of high-risk coronary atherosclerosis at CCTA with clinical and circulating biomarkers

T2 - Insight from CAPIRE study

AU - Conte, Edoardo

AU - Andreini, Daniele

AU - Magnoni, Marco

AU - Masson, Serge

AU - Mushtaq, Saima

AU - Berti, Sergio

AU - Canestrari, Mauro

AU - Casolo, Giancarlo

AU - Gabrielli, Domenico

AU - Latini, R.

AU - Marraccini, Paolo

AU - Moccetti, Tiziano

AU - Modena, Maria Grazia

AU - Pontone, Gianluca

AU - Gorini, Marco

AU - Maggioni, Aldo P.

AU - Maseri, Attilio

AU - Gaspari, F.

AU - Ferrari, S.

AU - Cannata, A.

AU - Stucchi, N.

AU - Fois, M.

AU - Bernasconi, R.

AU - Balconi, G.

AU - Vago, T.

AU - Letizia, T.

AU - Bottazzi, B.

AU - Leone, R.

AU - Suliman, I.

AU - Sommaruga, M.

AU - Gremigni, P.

AU - Olivieri, R.

AU - Pennacchietti, L.

AU - Magnacca, M.

AU - Rossi, M. G.

AU - Pasotti, E.

AU - Clemente, A.

AU - Mushtaq, S.

AU - Mauro, E.

AU - Pigazzani, F.

N1 - Funding Information: Daniele Andreini declares the following conflict of interest: speaker bureau for GE Healthcare, research grant (to the Institution) from GE Healthcare and Bracco. The other authors have nothing to declare. Gianluca Pontone declares the following conflict of interest: Institutional fee as speaker and/or research grant from GE Helthcare, Bracco, Bayer, Medtronic, Heartflow. Funding Information: The study is promoted by GISSI Group (ANMCO, Mario Negri Institute and Heart Care Foundation Onlus). The sponsor of the study is the Heart Care Foundation Onlus, an independent non-profit institution. The study is partially supported by an unrestricted grant by Ferrero Spa and from the contributions collected by the Heart Care Foundation Onlus, in the years 2009 and 2010, from the fundraising campaigns “Accendi il tuo cuore". Publisher Copyright: © 2020 Society of Cardiovascular Computed Tomography

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Background: High-risk coronary atherosclerosis features evaluated coronary CT angiography (CCTA) were suggested to have a prognostic role. The present study aimed to evaluate the association of circulating biomarkers with high-risk plaque features assessed by CCTA. Methods: A consecutive cohort of subjects who underwent CCTA because of suspected CAD was screened for inclusion in the CAPIRE study. Based on risk factors (RF) burden patients were defined as having a low clinical risk (0–1 RF with the exclusion of patients with diabetes mellitus as single RF) or an high clinical risk (≥3 RFs). In all patients, measurement of inflammatory biomarkers and CCTA analysis focused on high-risk plaque features were performed. Univariate and multivariate logistic regression analysis were used to evaluate the relationship between clinical and biological variables with CCTA advanced plaque features. Results: 528 patients were enrolled in CAPIRE study. Older age and male sex appeared to be predictors of qualitative high-risk plaque features and associated with the presence of elevated total, non-calcified and low-attenuation plaque volume. Among circulating biomarkers only hs-CRP was found to be associated with qualitative high-risk plaque features (OR 2.02, p = 0.004 and 2.02, p = 0.012 for LAP and RI > 1.1, respectively) with borderline association with LAP-Vol (OR 1.52, p = 0.076); HbA1c and PTX-3 resulted to be significantly associated with quantitative high-risk plaque features (OR 1.71, p = 0.003 and 1.04, p = 0.002 for LAP-Vol, respectively). Conclusions: Our results support the association between inflammatory biomarkers (hs-CRP, PTX- 3), HbA1c and high-risk atherosclerotic features detected by CCTA. Male sex and older age are significant predictors of high-risk atherosclerosis.

AB - Background: High-risk coronary atherosclerosis features evaluated coronary CT angiography (CCTA) were suggested to have a prognostic role. The present study aimed to evaluate the association of circulating biomarkers with high-risk plaque features assessed by CCTA. Methods: A consecutive cohort of subjects who underwent CCTA because of suspected CAD was screened for inclusion in the CAPIRE study. Based on risk factors (RF) burden patients were defined as having a low clinical risk (0–1 RF with the exclusion of patients with diabetes mellitus as single RF) or an high clinical risk (≥3 RFs). In all patients, measurement of inflammatory biomarkers and CCTA analysis focused on high-risk plaque features were performed. Univariate and multivariate logistic regression analysis were used to evaluate the relationship between clinical and biological variables with CCTA advanced plaque features. Results: 528 patients were enrolled in CAPIRE study. Older age and male sex appeared to be predictors of qualitative high-risk plaque features and associated with the presence of elevated total, non-calcified and low-attenuation plaque volume. Among circulating biomarkers only hs-CRP was found to be associated with qualitative high-risk plaque features (OR 2.02, p = 0.004 and 2.02, p = 0.012 for LAP and RI > 1.1, respectively) with borderline association with LAP-Vol (OR 1.52, p = 0.076); HbA1c and PTX-3 resulted to be significantly associated with quantitative high-risk plaque features (OR 1.71, p = 0.003 and 1.04, p = 0.002 for LAP-Vol, respectively). Conclusions: Our results support the association between inflammatory biomarkers (hs-CRP, PTX- 3), HbA1c and high-risk atherosclerotic features detected by CCTA. Male sex and older age are significant predictors of high-risk atherosclerosis.

KW - Cardiac computed tomography

KW - Cardiovascular prevention

KW - Coronary atherosclerosis

KW - Coronary plaque

KW - High-risk plaque features

KW - Inflammation

UR - https://www.scopus.com/pages/publications/85086508540

U2 - 10.1016/j.jcct.2020.03.005

DO - 10.1016/j.jcct.2020.03.005

M3 - Article

C2 - 32563713

AN - SCOPUS:85086508540

SN - 1934-5925

VL - 15

SP - 73

EP - 80

JO - Journal of Cardiovascular Computed Tomography

JF - Journal of Cardiovascular Computed Tomography

IS - 1

ER -

Association of high-risk coronary atherosclerosis at CCTA with clinical and circulating biomarkers: Insight from CAPIRE study

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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